Study on the anti-Parkinson's disease activity mechanism and preparation of panaxadiol

Traditional Chinese medicine offers unique and valuable resources for the exploration of novel approaches to disease treatment. Panaxadiol, an active compound derived from the transformation of ginsenosides. It has a variety of pharmacological activities. However, there is a lack of research regardi...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2025-01, Vol.136, p.156296, Article 156296
Hauptverfasser:	Xu, Lei, Zhang, Zhongjin, Feng, Ziqi, Niu, Sixiang, Yang, Lixia, Xiao, Baoguo, Jin, Xiao-ming, Ma, Cungen, Fan, Huijie, Xiao, Shengnan, Chai, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Animals blood-brain barrier Blood-Brain Barrier - drug effects Cell Line cytotoxicity Deep eutectic solvent (NADES) Disease Models, Animal Dopaminergic Neurons - drug effects Gastrointestinal Microbiome - drug effects ginsenosides Ginsenosides - pharmacology Inflammation Intestinal flora intestinal microorganisms intestines Lipopolysaccharides Male Mice Mice, Inbred C57BL microbial communities Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism Oriental traditional medicine Panaxadiol Parkinson disease Parkinson Disease - drug therapy Parkinson's disease (PD) response surface methodology Signal Transduction - drug effects solvents Substantia Nigra - drug effects therapeutics Toll-Like Receptor 4 - metabolism viability
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