Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins

Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This study evaluates the roles of immune checkpoint receptors on NK cell phenotype and functions both before and after circulation through tumor tissue. Twenty non-small cell lung ca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunologic research 2025-12, Vol.73 (1), p.18-18, Article 18
Hauptverfasser:	Esen, Fehim, Cikman, Duygu Ilke, Engin, Ayse, Turna, Akif, Batur, Sebnem, Oz, Buge, Turna, Hande Zeynep, Deniz, Gunnur, Aktas Cetin, Esin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergology Antigens, CD - blood Antigens, CD - metabolism Biomedical and Life Sciences Biomedicine blood Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology CD223 antigen cell structures Comparative analysis CTLA-4 Antigen - blood CTLA-4 Antigen - immunology CTLA-4 Antigen - metabolism CTLA-4 protein Cytokines Cytokines - blood Cytokines - metabolism Cytotoxicity Cytotoxicity, Immunologic Female Flow cytometry Genotype & phenotype Humans Immune checkpoint Immune status immunity Immunology Immunophenotyping interleukin-10 Internal Medicine Killer Cells, Natural - immunology Lung cancer lung neoplasms Lung Neoplasms - blood Lung Neoplasms - immunology Lung Neoplasms - pathology Lymphocyte Activation Gene 3 Protein Lymphocytes Lymphoid cells Male Medicine/Public Health Middle Aged Natural killer cells Non-small cell lung carcinoma PD-1 protein Perforin Peripheral blood phenotype Phenotypes Programmed Cell Death 1 Receptor - metabolism Receptors, Immunologic - blood Receptors, Immunologic - metabolism secretion Small cell lung carcinoma surgery Tumor microenvironment Tumor Microenvironment - immunology Tumors Veins Veins & arteries
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!