Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis
•This aerobic activity with cognitive overload had a greater effect than aerobic activity in patients with RRMS.•Probably, repeating positive words and motivational sentences and performing aerobic exercises at the same time, even with moderate intensity, can affect some aspects related to MS diseas...
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| creator | Farajnia, Sara Rajabi, Hamid Ghaffari, Mehran Beladi-Moghadam, Nahid Fayazmilani, Rana |
| description | •This aerobic activity with cognitive overload had a greater effect than aerobic activity in patients with RRMS.•Probably, repeating positive words and motivational sentences and performing aerobic exercises at the same time, even with moderate intensity, can affect some aspects related to MS disease.•Prescribing this type of combined training for patients with MS in exercise programs is a possible effective approach.
Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neurodegeneration, leading to various physical, cognitive, and emotional challenges. Dual-task (DT) training, involving performing mental and physical tasks simultaneously, addresses the complex interaction between motor and cognitive functions.
Given the extensive physical, cognitive, and mood-related issues in this population, this study aimed to examine the effects of combined aerobic-cognitive training (Brythonic) and aerobic training on brain-derived neurotrophic factor (BDNF), DT performance, and mood state in MS patients.
Thirty patients (22 women and 8 men) with relapsing-remitting multiple sclerosis (RRMS) and an expanded disability status scale (EDSS) score below four were randomly assigned to three groups: aerobic-cognitive training (Brythonic), aerobic training, and control. The training groups participated in 10 weeks of home-based online training, with two sessions per week. Each session included a 10-minute warmup, 15 to 35 min of exercise, and a 5-minute cool-down. The Brythonic group performed aerobic movements while reciting motivational words, forming a complete positive sentence over ten weeks. The aerobic group performed the same movements without cognitive tasks. Serum BDNF levels, DT performance, and profile of mood states (POMS) were measured before and after the 10-week training period. A two-way ANOVA with repeated measures was used to analyze differences between and within groups, with a significance level of P ≤ 0.05.
BDNF levels significantly increased in the Brythonic group (P = 0.048) and significantly decreased in the control group compared to baseline. In the DT test, the Brythonic group showed significant improvements in the number of correct answers and DT values compared to the aerobic and control groups. The Brythonic group also had a significantly reduced response time compared to the control group. Additionally, selective speed significantly increased in both training groups. In the POMS test, the Brythonic grou |
| doi_str_mv | 10.1016/j.physbeh.2024.114756 |
| format | Article |
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Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neurodegeneration, leading to various physical, cognitive, and emotional challenges. Dual-task (DT) training, involving performing mental and physical tasks simultaneously, addresses the complex interaction between motor and cognitive functions.
Given the extensive physical, cognitive, and mood-related issues in this population, this study aimed to examine the effects of combined aerobic-cognitive training (Brythonic) and aerobic training on brain-derived neurotrophic factor (BDNF), DT performance, and mood state in MS patients.
Thirty patients (22 women and 8 men) with relapsing-remitting multiple sclerosis (RRMS) and an expanded disability status scale (EDSS) score below four were randomly assigned to three groups: aerobic-cognitive training (Brythonic), aerobic training, and control. The training groups participated in 10 weeks of home-based online training, with two sessions per week. Each session included a 10-minute warmup, 15 to 35 min of exercise, and a 5-minute cool-down. The Brythonic group performed aerobic movements while reciting motivational words, forming a complete positive sentence over ten weeks. The aerobic group performed the same movements without cognitive tasks. Serum BDNF levels, DT performance, and profile of mood states (POMS) were measured before and after the 10-week training period. A two-way ANOVA with repeated measures was used to analyze differences between and within groups, with a significance level of P ≤ 0.05.
BDNF levels significantly increased in the Brythonic group (P = 0.048) and significantly decreased in the control group compared to baseline. In the DT test, the Brythonic group showed significant improvements in the number of correct answers and DT values compared to the aerobic and control groups. The Brythonic group also had a significantly reduced response time compared to the control group. Additionally, selective speed significantly increased in both training groups. In the POMS test, the Brythonic group showed significant improvements in all items except depression compared to the control group. Within the Brythonic group, all items significantly improved from baseline.
This study demonstrated that combining motivational words with aerobic movements significantly impacts BDNF levels, DT performance, and mood states. Adding mental exertion to physical activity appears beneficial for patients with MS. Future studies should re-examine these findings with a larger patient cohort.</description><identifier>ISSN: 0031-9384</identifier><identifier>ISSN: 1873-507X</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2024.114756</identifier><identifier>PMID: 39579951</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Affect - physiology ; BDNF ; behavior ; blood serum ; Brain-Derived Neurotrophic Factor - blood ; Brythonic ; cognition ; Cognition - physiology ; Cognitive Impairment ; emotions ; exercise ; Exercise - physiology ; Exercise Therapy - methods ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting - blood ; Multiple Sclerosis, Relapsing-Remitting - physiopathology ; Multiple Sclerosis, Relapsing-Remitting - psychology ; Multiple Sclerosis, Relapsing-Remitting - rehabilitation ; neurodegenerative diseases ; patients ; Physical Activity ; Psychomotor Performance - physiology ; sclerosis ; Vitality Principle of Training</subject><ispartof>Physiology & behavior, 2025-03, Vol.290, p.114756, Article 114756</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-92770d5e10ab7e7d707307668c5d9f7bb34719dd192068448bdc211d75c411353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938424003044$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39579951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farajnia, Sara</creatorcontrib><creatorcontrib>Rajabi, Hamid</creatorcontrib><creatorcontrib>Ghaffari, Mehran</creatorcontrib><creatorcontrib>Beladi-Moghadam, Nahid</creatorcontrib><creatorcontrib>Fayazmilani, Rana</creatorcontrib><title>Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>•This aerobic activity with cognitive overload had a greater effect than aerobic activity in patients with RRMS.•Probably, repeating positive words and motivational sentences and performing aerobic exercises at the same time, even with moderate intensity, can affect some aspects related to MS disease.•Prescribing this type of combined training for patients with MS in exercise programs is a possible effective approach.
Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neurodegeneration, leading to various physical, cognitive, and emotional challenges. Dual-task (DT) training, involving performing mental and physical tasks simultaneously, addresses the complex interaction between motor and cognitive functions.
Given the extensive physical, cognitive, and mood-related issues in this population, this study aimed to examine the effects of combined aerobic-cognitive training (Brythonic) and aerobic training on brain-derived neurotrophic factor (BDNF), DT performance, and mood state in MS patients.
Thirty patients (22 women and 8 men) with relapsing-remitting multiple sclerosis (RRMS) and an expanded disability status scale (EDSS) score below four were randomly assigned to three groups: aerobic-cognitive training (Brythonic), aerobic training, and control. The training groups participated in 10 weeks of home-based online training, with two sessions per week. Each session included a 10-minute warmup, 15 to 35 min of exercise, and a 5-minute cool-down. The Brythonic group performed aerobic movements while reciting motivational words, forming a complete positive sentence over ten weeks. The aerobic group performed the same movements without cognitive tasks. Serum BDNF levels, DT performance, and profile of mood states (POMS) were measured before and after the 10-week training period. A two-way ANOVA with repeated measures was used to analyze differences between and within groups, with a significance level of P ≤ 0.05.
BDNF levels significantly increased in the Brythonic group (P = 0.048) and significantly decreased in the control group compared to baseline. In the DT test, the Brythonic group showed significant improvements in the number of correct answers and DT values compared to the aerobic and control groups. The Brythonic group also had a significantly reduced response time compared to the control group. Additionally, selective speed significantly increased in both training groups. In the POMS test, the Brythonic group showed significant improvements in all items except depression compared to the control group. Within the Brythonic group, all items significantly improved from baseline.
This study demonstrated that combining motivational words with aerobic movements significantly impacts BDNF levels, DT performance, and mood states. Adding mental exertion to physical activity appears beneficial for patients with MS. Future studies should re-examine these findings with a larger patient cohort.</description><subject>Adult</subject><subject>Affect - physiology</subject><subject>BDNF</subject><subject>behavior</subject><subject>blood serum</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Brythonic</subject><subject>cognition</subject><subject>Cognition - physiology</subject><subject>Cognitive Impairment</subject><subject>emotions</subject><subject>exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis, Relapsing-Remitting - blood</subject><subject>Multiple Sclerosis, Relapsing-Remitting - physiopathology</subject><subject>Multiple Sclerosis, Relapsing-Remitting - psychology</subject><subject>Multiple Sclerosis, Relapsing-Remitting - rehabilitation</subject><subject>neurodegenerative diseases</subject><subject>patients</subject><subject>Physical Activity</subject><subject>Psychomotor Performance - physiology</subject><subject>sclerosis</subject><subject>Vitality Principle of Training</subject><issn>0031-9384</issn><issn>1873-507X</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2OFCEUhYnROO3oI2hYuphqofhrVsZM_JlkEjeauCMU3JqmrSpKoNqZx_FNpdKtWyUkkNzvnMvlIPSSki0lVL45bOf9Q-5gv21Jy7eUciXkI7ShO8UaQdS3x2hDCKONZjt-gZ7lfCB1Mc6eogumhdJa0A36dTPO1hUce-zi3RRKOEJjIcUuOAz3kFzIgEuyYQrTHY4T7tZ74yFV0uMJlhRLivO-8n11iukK-8UOTbH5-yqxXRiqLeQrbCePxxg9zsUWwGGq24djWPmMf4ayx-MylDAPgLMb6ityyM_Rk76W4cX5vERfP7z_cv2puf388eb63W3jWiVLo1uliBdAie0UKK-IYkRJuXPC6151HeOKau-pbonccb7rvGsp9Uo4TikT7BK9PvnOKf5YIBczhuxgGOwEccmGUcFbLrmU_4GylkmhNamoOKGuDpMT9GZOYbTpwVBi1iDNwZyDNGuQ5hRk1b06t1i6Efxf1Z_kKvD2BED9k2OAZLILMDnwIYErxsfwjxa_AVNMtF8</recordid><startdate>20250301</startdate><enddate>20250301</enddate><creator>Farajnia, Sara</creator><creator>Rajabi, Hamid</creator><creator>Ghaffari, Mehran</creator><creator>Beladi-Moghadam, Nahid</creator><creator>Fayazmilani, Rana</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20250301</creationdate><title>Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis</title><author>Farajnia, Sara ; Rajabi, Hamid ; Ghaffari, Mehran ; Beladi-Moghadam, Nahid ; Fayazmilani, Rana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-92770d5e10ab7e7d707307668c5d9f7bb34719dd192068448bdc211d75c411353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Affect - physiology</topic><topic>BDNF</topic><topic>behavior</topic><topic>blood serum</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Brythonic</topic><topic>cognition</topic><topic>Cognition - physiology</topic><topic>Cognitive Impairment</topic><topic>emotions</topic><topic>exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis, Relapsing-Remitting - blood</topic><topic>Multiple Sclerosis, Relapsing-Remitting - physiopathology</topic><topic>Multiple Sclerosis, Relapsing-Remitting - psychology</topic><topic>Multiple Sclerosis, Relapsing-Remitting - rehabilitation</topic><topic>neurodegenerative diseases</topic><topic>patients</topic><topic>Physical Activity</topic><topic>Psychomotor Performance - physiology</topic><topic>sclerosis</topic><topic>Vitality Principle of Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farajnia, Sara</creatorcontrib><creatorcontrib>Rajabi, Hamid</creatorcontrib><creatorcontrib>Ghaffari, Mehran</creatorcontrib><creatorcontrib>Beladi-Moghadam, Nahid</creatorcontrib><creatorcontrib>Fayazmilani, Rana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farajnia, Sara</au><au>Rajabi, Hamid</au><au>Ghaffari, Mehran</au><au>Beladi-Moghadam, Nahid</au><au>Fayazmilani, Rana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2025-03-01</date><risdate>2025</risdate><volume>290</volume><spage>114756</spage><pages>114756-</pages><artnum>114756</artnum><issn>0031-9384</issn><issn>1873-507X</issn><eissn>1873-507X</eissn><abstract>•This aerobic activity with cognitive overload had a greater effect than aerobic activity in patients with RRMS.•Probably, repeating positive words and motivational sentences and performing aerobic exercises at the same time, even with moderate intensity, can affect some aspects related to MS disease.•Prescribing this type of combined training for patients with MS in exercise programs is a possible effective approach.
Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neurodegeneration, leading to various physical, cognitive, and emotional challenges. Dual-task (DT) training, involving performing mental and physical tasks simultaneously, addresses the complex interaction between motor and cognitive functions.
Given the extensive physical, cognitive, and mood-related issues in this population, this study aimed to examine the effects of combined aerobic-cognitive training (Brythonic) and aerobic training on brain-derived neurotrophic factor (BDNF), DT performance, and mood state in MS patients.
Thirty patients (22 women and 8 men) with relapsing-remitting multiple sclerosis (RRMS) and an expanded disability status scale (EDSS) score below four were randomly assigned to three groups: aerobic-cognitive training (Brythonic), aerobic training, and control. The training groups participated in 10 weeks of home-based online training, with two sessions per week. Each session included a 10-minute warmup, 15 to 35 min of exercise, and a 5-minute cool-down. The Brythonic group performed aerobic movements while reciting motivational words, forming a complete positive sentence over ten weeks. The aerobic group performed the same movements without cognitive tasks. Serum BDNF levels, DT performance, and profile of mood states (POMS) were measured before and after the 10-week training period. A two-way ANOVA with repeated measures was used to analyze differences between and within groups, with a significance level of P ≤ 0.05.
BDNF levels significantly increased in the Brythonic group (P = 0.048) and significantly decreased in the control group compared to baseline. In the DT test, the Brythonic group showed significant improvements in the number of correct answers and DT values compared to the aerobic and control groups. The Brythonic group also had a significantly reduced response time compared to the control group. Additionally, selective speed significantly increased in both training groups. In the POMS test, the Brythonic group showed significant improvements in all items except depression compared to the control group. Within the Brythonic group, all items significantly improved from baseline.
This study demonstrated that combining motivational words with aerobic movements significantly impacts BDNF levels, DT performance, and mood states. Adding mental exertion to physical activity appears beneficial for patients with MS. Future studies should re-examine these findings with a larger patient cohort.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39579951</pmid><doi>10.1016/j.physbeh.2024.114756</doi></addata></record> |
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| subjects | Adult Affect - physiology BDNF behavior blood serum Brain-Derived Neurotrophic Factor - blood Brythonic cognition Cognition - physiology Cognitive Impairment emotions exercise Exercise - physiology Exercise Therapy - methods Female Humans Male Middle Aged Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - physiopathology Multiple Sclerosis, Relapsing-Remitting - psychology Multiple Sclerosis, Relapsing-Remitting - rehabilitation neurodegenerative diseases patients Physical Activity Psychomotor Performance - physiology sclerosis Vitality Principle of Training |
| title | Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis |
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