Quercetin 7-rhamnoside from Sorbaria sorbifolia exerts anti-hepatocellular carcinoma effect via DHRS13/apoptotic pathway

•For the first time, it has been discovered that the component Quercetin 7-rhamnoside (Q7R) from Sorbaria sorbifolia exhibits notable anti-hepatocellular carcinoma efficacy.•The abnormal expression of DHRS13 protein was found in liver cancer tissues, and Q7R can lower liver cancer cell proliferation...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-12, Vol.135, p.156031, Article 156031
Hauptverfasser:	Xu, Zhaohua, Dang, Ying, Chen, Xu, Hai, Yao, Wenzhi, Kou, Wenchao, Zhang, Jiamei, Shi, Jianping, Dong, Yu, Li, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Animals Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Apoptosis signaling pathway bioinformatics carcinoma Carcinoma, Hepatocellular - drug therapy cell cycle cell growth Danio rerio DHRS13 Hep G2 Cells Hepatocellular carcinoma hepatoma human cell lines Humans Lentivirus Liver Neoplasms - drug therapy Molecular Docking Simulation pharmacology prognosis protein synthesis quercetin Quercetin - analogs & derivatives Quercetin - pharmacology Quercetin 7-rhamnoside Sorbaria sorbifolia transfection Western blotting xenotransplantation Zebrafish
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