Alternative splicing events driven by altered levels of GEMIN5 undergo translation

GEMIN5 is a multifunctional protein involved in various aspects of RNA biology, including biogenesis of snRNPs and translation control. Reduced levels of GEMIN5 confer a differential translation to selective groups of mRNAs, and biallelic variants reducing protein stability or inducing structural co...

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Veröffentlicht in:	RNA biology 2024-12, Vol.21 (1), p.871-882
Hauptverfasser:	Francisco-Velilla, Rosario, Abellan, Salvador, Garcia-Martin, Juan Antonio, Oliveros, Juan Carlos, Martinez-Salas, Encarnacion
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing biogenesis cell growth Exons GEMIN5 gene expression Gene Expression Regulation HeLa Cells Humans open reading frames polyribosomes Polyribosomes - genetics Polyribosomes - metabolism polysome enrichment Protein Biosynthesis protein synthesis RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA-sequencing sequence analysis SMN complex SMN Complex Proteins - genetics SMN Complex Proteins - metabolism translation control
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