Decomposition of L-glutamine and accumulation of ammonium in cell culture media inhibit infectivity of influenza viruses

Cationic lysosomotropic molecules such as ammonium salts and chloroquine inhibit influenza A virus (IAV) infection in cell culture by counteracting endosomal acidification and hampering viral-endosomal fusion. Here, we studied the effects of storage of L-glutamine-supplemented cell culture media on...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2025-01, Vol.602, p.110314, Article 110314
Hauptverfasser:	Kegel, Nathanael B., Kaufmann, Andreas, Matrosovich, Mikhail, Bauer, Stefan, Dorna, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	acidification Ammonium Ammonium Compounds - metabolism Ammonium Compounds - pharmacology Animals Antiviral Agents - pharmacology Cell culture chloroquine Culture Media - chemistry Dogs Endosomal acidification glutamine Glutamine - metabolism Glutamine - pharmacology hemagglutinins Humans influenza Influenza A virus Influenza A virus - drug effects Influenza A virus - physiology L-glutamine Madin Darby Canine Kidney Cells pathogenicity virology Virus inactivation
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