Engineered bispecific antibodies with enhanced breadth and potency against SARS-CoV-2 variants and SARS-related coronaviruses

The concern of COVID-19 persists due to the continuous emergence of variants and the potential spillover of animal coronaviruses. The broad-spectrum neutralizing antibodies play a pivotal role in the prevention and treatment of coronavirus (CoV) infections. Here, we constructed 18 bi-specific antibo...

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Veröffentlicht in:	Medical microbiology and immunology 2024-12, Vol.213 (1), p.24-24, Article 24
Hauptverfasser:	Chang, Fangfang, Wu, Qian, Hu, Yabin, Pan, Zhendong, Liu, Yong-Chen, Li, Yue-Zhou, Bostina, Mihnea, Liu, Wenpei, Zhao, Ping, Qu, Xiaowang, Li, Yi-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Biomedical and Life Sciences Biomedicine Bispecific antibodies Coronaviridae Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - virology COVID-19 infection domain Humans Immunoglobulins Immunology inhibitory concentration 50 median effective concentration Medical Microbiology neutralization Neutralization Tests Protein Engineering SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus - immunology Spike Glycoprotein, Coronavirus - immunology Virology viruses
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