Sodium-glucose cotransporter 2 inhibitors ameliorate ER stress-induced pro-inflammatory cytokine expression by inhibiting CD36 in NAFLD progression in vitro

Sodium-dependent glucose cotransporter-2 (SGLT2) inhibitors, antidiabetic drugs that reduce blood sugar levels by inhibiting glucose reabsorption in the renal proximal tubules, also ameliorate nonalcoholic fatty liver disease (NAFLD). This study aimed to examine the effects of SGLT2 inhibition on he...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-11, Vol.735, p.150620, Article 150620
Hauptverfasser:	Lee, Jinmi, Hong, Seok-Woo, Kim, Min-Jeong, Lim, Yu-Mi, Moon, Sun Joon, Kwon, Hyemi, Park, Se Eun, Rhee, Eun-Jung, Lee, Won-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzhydryl Compounds - pharmacology Benzylidene Compounds - pharmacology blood glucose CD36 CD36 Antigens - genetics CD36 Antigens - metabolism coculture Cytokines - metabolism Disease Progression Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects exocytosis fatty liver gene expression genes glucose Glucosides - pharmacology Hep G2 Cells Humans Inflammation interleukin-6 lipopolysaccharides Mice Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis palmitic acid Palmitic Acid - pharmacology protein synthesis RAW 264.7 Cells resorption Sodium-dependent glucose cotransporter-2 Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 Inhibitors - pharmacology symporters transfection
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