Transmembrane and coiled-coil domain family 3 gene is a novel target of hepatic peroxisome proliferator-activated receptor γ in fatty liver disease

The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor abundantly expressed in the nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the mechanism by which PPARγ regulates the transmembrane and coiled-coil domain family 3 (Tmcc3) gene in the liver....

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Veröffentlicht in:	Molecular and cellular endocrinology 2024-12, Vol.594, p.112379, Article 112379
Hauptverfasser:	Aibara, Daisuke, Sakaguchi, Ai, Matsusue, Kimihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals domain endocrinology exons family fatty liver Fatty liver disease Gene Expression Regulation Humans liver Liver - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology noninsulin-dependent diabetes mellitus Nuclear receptor Peroxisome proliferator-activated receptor gamma PPAR gamma - genetics PPAR gamma - metabolism Transmembrane and coiled-coil domain family 3
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