Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment

Silicosis is a serious silica-induced respiratory disease for which there is currently no effective treatment. Irreversible pulmonary fibrosis caused by persistent inflammation is the main feature of silicosis. As an underlying mechanism, acetylation regulated by histone deacetylases (HDACs) are bel...

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Veröffentlicht in:	Journal of controlled release 2023-12, Vol.364, p.618-631
Hauptverfasser:	Tian, Yunze, Shi, Hongyang, Zhang, Danjie, Wang, Chenfei, Zhao, Feng, Li, Liang, Xu, Zhengshui, Jiang, Jiantao, Li, Jianzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylated modification Acetylation Animals atomization breathing DNA gene expression regulation HDAC10 histone deacetylase Histone Deacetylases - adverse effects Histone Deacetylases - metabolism Inflammation Linear poly(β-amino ester)s lung function lungs macrophages Mice NF-kappa B - metabolism oxidative stress phosphorylation Proteomics Pulmonary Fibrosis Reactive Oxygen Species Silicon Dioxide Silicosis Silicosis - drug therapy Silicosis - metabolism transcriptomics
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