Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin
This study aimed to evaluate the spermotoxic potential of triazophos in rats and to check the possible shielding effect of quercetin and nano-quercetin against triazophos-induced toxicity. Rats in Group I were given olive oil as a vehicle. Group II and Group III received high-dose and low-dose triaz...
Gespeichert in:
| Veröffentlicht in: | Pesticide biochemistry and physiology 2024-11, Vol.205, p.106176, Article 106176 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 106176 |
| container_title | Pesticide biochemistry and physiology |
| container_volume | 205 |
| creator | Suhas, K.S. Vijapure, Shubham Yadav, Supriya Saminathan, M. Jambagi, Kaveri Katiyar, Rahul Madhu, C.L. Telang, Avinash G. |
| description | This study aimed to evaluate the spermotoxic potential of triazophos in rats and to check the possible shielding effect of quercetin and nano-quercetin against triazophos-induced toxicity. Rats in Group I were given olive oil as a vehicle. Group II and Group III received high-dose and low-dose triazophos, respectively. Oral administration of quercetin (Group IV) and nano-quercetin (Group VI) at a dose of 50 mg/kg body weight was given to two additional groups of animals. Two other high-dose triazophos groups were co-administered with quercetin (Group V) and nano-quercetin (Group VII).
Triazophos administration for 60 days in rats altered the structural and functional parameters of spermatozoa and brought about a decline in total sperm count, percentage of viable sperms, drop in sperm motility, and decrease in the number of sperms showing normal morphology. It also decreased the number of spermatozoa with intact acrosomes and HOST-positive spermatozoa. Further, triazophos increased the levels of reactive oxygen species and triggered apoptotic pathways in spermatozoa in a dose-dependent manner. It decreased daily sperm production and caused histomorphological aberrations in the epididymis and vas deferens. Co-administration of nano-quercetin with triazophos effectively counteracted sperm-related pathological changes. Nano-quercetin offered better protection over quercetin in ameliorating the triazophos-induced spermotoxicity in rats.
[Display omitted]
•Triazophos caused a decline in sperm count, structure and function.•Triazophos induced oxidative stress and triggered apoptosis in rat spermatozoa.•Nano-quercetin lessened triazophos-induced sperm toxicity by antioxidant action. |
| doi_str_mv | 10.1016/j.pestbp.2024.106176 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3154177124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0048357524004097</els_id><sourcerecordid>3154177124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c274t-283f06797e6b54d017856f22392f29f1f28b396114904d339eb212818ee6a52d3</originalsourceid><addsrcrecordid>eNqNkMtKAzEUhoMotl7eQGSWbqbmNsnEhSDFGxTqoq7DXE4wpZ2MSSrWpzdlqktxdQ6H7z8_fAhdEDwhmIjr5aSHEOt-QjHl6SSIFAdoTLAqcqWYOkRjjHmZs0IWI3QSwhJjrDhWx2jEFJeykGyM5gtvqy_Xv7mQ267dNNBmoQe_dtF92sbGbWa7zFcx3GQv3kVoov2ADIxJW8icybqqc_n7BnwD0XZn6MhUqwDn-3mKXh_uF9OnfDZ_fJ7ezfKGSh5zWjKDhVQSRF3wFhNZFsJQyhQ1VBliaFkzJQjhCvOWMQU1JbQkJYCoCtqyU3Q1_O29S-Uh6rUNDaxWVQduEzQjBSdSEsr_gVIqmGRYJpQPaONdCB6M7r1dV36rCdY763qpB-t6Z10P1lPsct-wqdfQ_oZ-NCfgdgAgKfmw4HVoLHRJtvXJo26d_bvhG7KqlAo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3122637307</pqid></control><display><type>article</type><title>Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Suhas, K.S. ; Vijapure, Shubham ; Yadav, Supriya ; Saminathan, M. ; Jambagi, Kaveri ; Katiyar, Rahul ; Madhu, C.L. ; Telang, Avinash G.</creator><creatorcontrib>Suhas, K.S. ; Vijapure, Shubham ; Yadav, Supriya ; Saminathan, M. ; Jambagi, Kaveri ; Katiyar, Rahul ; Madhu, C.L. ; Telang, Avinash G.</creatorcontrib><description>This study aimed to evaluate the spermotoxic potential of triazophos in rats and to check the possible shielding effect of quercetin and nano-quercetin against triazophos-induced toxicity. Rats in Group I were given olive oil as a vehicle. Group II and Group III received high-dose and low-dose triazophos, respectively. Oral administration of quercetin (Group IV) and nano-quercetin (Group VI) at a dose of 50 mg/kg body weight was given to two additional groups of animals. Two other high-dose triazophos groups were co-administered with quercetin (Group V) and nano-quercetin (Group VII).
Triazophos administration for 60 days in rats altered the structural and functional parameters of spermatozoa and brought about a decline in total sperm count, percentage of viable sperms, drop in sperm motility, and decrease in the number of sperms showing normal morphology. It also decreased the number of spermatozoa with intact acrosomes and HOST-positive spermatozoa. Further, triazophos increased the levels of reactive oxygen species and triggered apoptotic pathways in spermatozoa in a dose-dependent manner. It decreased daily sperm production and caused histomorphological aberrations in the epididymis and vas deferens. Co-administration of nano-quercetin with triazophos effectively counteracted sperm-related pathological changes. Nano-quercetin offered better protection over quercetin in ameliorating the triazophos-induced spermotoxicity in rats.
[Display omitted]
•Triazophos caused a decline in sperm count, structure and function.•Triazophos induced oxidative stress and triggered apoptosis in rat spermatozoa.•Nano-quercetin lessened triazophos-induced sperm toxicity by antioxidant action.</description><identifier>ISSN: 0048-3575</identifier><identifier>ISSN: 1095-9939</identifier><identifier>EISSN: 1095-9939</identifier><identifier>DOI: 10.1016/j.pestbp.2024.106176</identifier><identifier>PMID: 39477573</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>acrosome ; Animals ; Antioxidants - pharmacology ; apoptosis ; Apoptosis - drug effects ; body weight ; dose response ; epididymis ; Insecticides - toxicity ; Male ; Nano-quercetin ; Nanoparticles - chemistry ; olive oil ; oral administration ; Organothiophosphates - toxicity ; Oxidative stress ; Quercetin ; Quercetin - pharmacology ; Rats ; Rats, Wistar ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; Sperm Count ; sperm motility ; Sperm Motility - drug effects ; spermatogenesis ; Spermatozoa ; Spermatozoa - drug effects ; Toxicity ; Triazoles - toxicity ; Triazophos</subject><ispartof>Pesticide biochemistry and physiology, 2024-11, Vol.205, p.106176, Article 106176</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c274t-283f06797e6b54d017856f22392f29f1f28b396114904d339eb212818ee6a52d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pestbp.2024.106176$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39477573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suhas, K.S.</creatorcontrib><creatorcontrib>Vijapure, Shubham</creatorcontrib><creatorcontrib>Yadav, Supriya</creatorcontrib><creatorcontrib>Saminathan, M.</creatorcontrib><creatorcontrib>Jambagi, Kaveri</creatorcontrib><creatorcontrib>Katiyar, Rahul</creatorcontrib><creatorcontrib>Madhu, C.L.</creatorcontrib><creatorcontrib>Telang, Avinash G.</creatorcontrib><title>Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin</title><title>Pesticide biochemistry and physiology</title><addtitle>Pestic Biochem Physiol</addtitle><description>This study aimed to evaluate the spermotoxic potential of triazophos in rats and to check the possible shielding effect of quercetin and nano-quercetin against triazophos-induced toxicity. Rats in Group I were given olive oil as a vehicle. Group II and Group III received high-dose and low-dose triazophos, respectively. Oral administration of quercetin (Group IV) and nano-quercetin (Group VI) at a dose of 50 mg/kg body weight was given to two additional groups of animals. Two other high-dose triazophos groups were co-administered with quercetin (Group V) and nano-quercetin (Group VII).
Triazophos administration for 60 days in rats altered the structural and functional parameters of spermatozoa and brought about a decline in total sperm count, percentage of viable sperms, drop in sperm motility, and decrease in the number of sperms showing normal morphology. It also decreased the number of spermatozoa with intact acrosomes and HOST-positive spermatozoa. Further, triazophos increased the levels of reactive oxygen species and triggered apoptotic pathways in spermatozoa in a dose-dependent manner. It decreased daily sperm production and caused histomorphological aberrations in the epididymis and vas deferens. Co-administration of nano-quercetin with triazophos effectively counteracted sperm-related pathological changes. Nano-quercetin offered better protection over quercetin in ameliorating the triazophos-induced spermotoxicity in rats.
[Display omitted]
•Triazophos caused a decline in sperm count, structure and function.•Triazophos induced oxidative stress and triggered apoptosis in rat spermatozoa.•Nano-quercetin lessened triazophos-induced sperm toxicity by antioxidant action.</description><subject>acrosome</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>body weight</subject><subject>dose response</subject><subject>epididymis</subject><subject>Insecticides - toxicity</subject><subject>Male</subject><subject>Nano-quercetin</subject><subject>Nanoparticles - chemistry</subject><subject>olive oil</subject><subject>oral administration</subject><subject>Organothiophosphates - toxicity</subject><subject>Oxidative stress</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Sperm Count</subject><subject>sperm motility</subject><subject>Sperm Motility - drug effects</subject><subject>spermatogenesis</subject><subject>Spermatozoa</subject><subject>Spermatozoa - drug effects</subject><subject>Toxicity</subject><subject>Triazoles - toxicity</subject><subject>Triazophos</subject><issn>0048-3575</issn><issn>1095-9939</issn><issn>1095-9939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKAzEUhoMotl7eQGSWbqbmNsnEhSDFGxTqoq7DXE4wpZ2MSSrWpzdlqktxdQ6H7z8_fAhdEDwhmIjr5aSHEOt-QjHl6SSIFAdoTLAqcqWYOkRjjHmZs0IWI3QSwhJjrDhWx2jEFJeykGyM5gtvqy_Xv7mQ267dNNBmoQe_dtF92sbGbWa7zFcx3GQv3kVoov2ADIxJW8icybqqc_n7BnwD0XZn6MhUqwDn-3mKXh_uF9OnfDZ_fJ7ezfKGSh5zWjKDhVQSRF3wFhNZFsJQyhQ1VBliaFkzJQjhCvOWMQU1JbQkJYCoCtqyU3Q1_O29S-Uh6rUNDaxWVQduEzQjBSdSEsr_gVIqmGRYJpQPaONdCB6M7r1dV36rCdY763qpB-t6Z10P1lPsct-wqdfQ_oZ-NCfgdgAgKfmw4HVoLHRJtvXJo26d_bvhG7KqlAo</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Suhas, K.S.</creator><creator>Vijapure, Shubham</creator><creator>Yadav, Supriya</creator><creator>Saminathan, M.</creator><creator>Jambagi, Kaveri</creator><creator>Katiyar, Rahul</creator><creator>Madhu, C.L.</creator><creator>Telang, Avinash G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202411</creationdate><title>Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin</title><author>Suhas, K.S. ; Vijapure, Shubham ; Yadav, Supriya ; Saminathan, M. ; Jambagi, Kaveri ; Katiyar, Rahul ; Madhu, C.L. ; Telang, Avinash G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-283f06797e6b54d017856f22392f29f1f28b396114904d339eb212818ee6a52d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acrosome</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>body weight</topic><topic>dose response</topic><topic>epididymis</topic><topic>Insecticides - toxicity</topic><topic>Male</topic><topic>Nano-quercetin</topic><topic>Nanoparticles - chemistry</topic><topic>olive oil</topic><topic>oral administration</topic><topic>Organothiophosphates - toxicity</topic><topic>Oxidative stress</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Sperm Count</topic><topic>sperm motility</topic><topic>Sperm Motility - drug effects</topic><topic>spermatogenesis</topic><topic>Spermatozoa</topic><topic>Spermatozoa - drug effects</topic><topic>Toxicity</topic><topic>Triazoles - toxicity</topic><topic>Triazophos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suhas, K.S.</creatorcontrib><creatorcontrib>Vijapure, Shubham</creatorcontrib><creatorcontrib>Yadav, Supriya</creatorcontrib><creatorcontrib>Saminathan, M.</creatorcontrib><creatorcontrib>Jambagi, Kaveri</creatorcontrib><creatorcontrib>Katiyar, Rahul</creatorcontrib><creatorcontrib>Madhu, C.L.</creatorcontrib><creatorcontrib>Telang, Avinash G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Pesticide biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suhas, K.S.</au><au>Vijapure, Shubham</au><au>Yadav, Supriya</au><au>Saminathan, M.</au><au>Jambagi, Kaveri</au><au>Katiyar, Rahul</au><au>Madhu, C.L.</au><au>Telang, Avinash G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin</atitle><jtitle>Pesticide biochemistry and physiology</jtitle><addtitle>Pestic Biochem Physiol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>205</volume><spage>106176</spage><pages>106176-</pages><artnum>106176</artnum><issn>0048-3575</issn><issn>1095-9939</issn><eissn>1095-9939</eissn><abstract>This study aimed to evaluate the spermotoxic potential of triazophos in rats and to check the possible shielding effect of quercetin and nano-quercetin against triazophos-induced toxicity. Rats in Group I were given olive oil as a vehicle. Group II and Group III received high-dose and low-dose triazophos, respectively. Oral administration of quercetin (Group IV) and nano-quercetin (Group VI) at a dose of 50 mg/kg body weight was given to two additional groups of animals. Two other high-dose triazophos groups were co-administered with quercetin (Group V) and nano-quercetin (Group VII).
Triazophos administration for 60 days in rats altered the structural and functional parameters of spermatozoa and brought about a decline in total sperm count, percentage of viable sperms, drop in sperm motility, and decrease in the number of sperms showing normal morphology. It also decreased the number of spermatozoa with intact acrosomes and HOST-positive spermatozoa. Further, triazophos increased the levels of reactive oxygen species and triggered apoptotic pathways in spermatozoa in a dose-dependent manner. It decreased daily sperm production and caused histomorphological aberrations in the epididymis and vas deferens. Co-administration of nano-quercetin with triazophos effectively counteracted sperm-related pathological changes. Nano-quercetin offered better protection over quercetin in ameliorating the triazophos-induced spermotoxicity in rats.
[Display omitted]
•Triazophos caused a decline in sperm count, structure and function.•Triazophos induced oxidative stress and triggered apoptosis in rat spermatozoa.•Nano-quercetin lessened triazophos-induced sperm toxicity by antioxidant action.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39477573</pmid><doi>10.1016/j.pestbp.2024.106176</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-3575 |
| ispartof | Pesticide biochemistry and physiology, 2024-11, Vol.205, p.106176, Article 106176 |
| issn | 0048-3575 1095-9939 1095-9939 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3154177124 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | acrosome Animals Antioxidants - pharmacology apoptosis Apoptosis - drug effects body weight dose response epididymis Insecticides - toxicity Male Nano-quercetin Nanoparticles - chemistry olive oil oral administration Organothiophosphates - toxicity Oxidative stress Quercetin Quercetin - pharmacology Rats Rats, Wistar reactive oxygen species Reactive Oxygen Species - metabolism Sperm Count sperm motility Sperm Motility - drug effects spermatogenesis Spermatozoa Spermatozoa - drug effects Toxicity Triazoles - toxicity Triazophos |
| title | Triazophos-induced spermotoxicity in rats: Protective effects of nano-quercetin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T11%3A20%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Triazophos-induced%20spermotoxicity%20in%20rats:%20Protective%20effects%20of%20nano-quercetin&rft.jtitle=Pesticide%20biochemistry%20and%20physiology&rft.au=Suhas,%20K.S.&rft.date=2024-11&rft.volume=205&rft.spage=106176&rft.pages=106176-&rft.artnum=106176&rft.issn=0048-3575&rft.eissn=1095-9939&rft_id=info:doi/10.1016/j.pestbp.2024.106176&rft_dat=%3Cproquest_cross%3E3154177124%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3122637307&rft_id=info:pmid/39477573&rft_els_id=S0048357524004097&rfr_iscdi=true |