Preparation of bovine coronavirus virus-like particles and its immunogenicity in mice and cattle

The widespread prevalence of bovine coronavirus (BCoV) disease worldwide has impacted the livestock industry economically. No effective vaccine is available in China. In this study, we produced BCoV virus-like particles (VLPs) containing E, M, N, S, and hemagglutinin-esterase (HE) proteins using a b...

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Veröffentlicht in:	Microbial pathogenesis 2024-12, Vol.197, p.107062, Article 107062
Hauptverfasser:	Yu, Qisheng, Zhu, Qing, Huang, Xiangyue, Wu, Jinbo, Zhou, Qun, Chen, Taoyun, Zhu, Chenxi, Ding, Lu, Deng, Gunan, Wang, Yi, Zhang, Zhaohui, Zhang, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animals antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology antigens Baculoviridae Baculoviridae - genetics blood serum Bovine coronavirus Cattle Cattle Diseases - immunology Cattle Diseases - prevention & control Cattle Diseases - virology China Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - veterinary Coronavirus, Bovine - genetics Coronavirus, Bovine - immunology Female immunization Immunogenicity Immunoglobulin G - blood interferon-gamma livestock and meat industry Mice Mice, Inbred BALB C mixed infection neutralization Neutralization Tests pathogenesis Sf9 Cells Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Vaccine vaccine development vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus-like particles
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