Controlled release, chitosan-tethered luteolin phytocubosomes; Formulation optimization to in-vivo antiglaucoma and anti-inflammatory ocular evaluation

A chitosan-coated luteolin-loaded phytocubosomal system was prepared to improve the pharmacodynamic performance of luteolin in the treatment of glaucoma and ocular inflammation after topical ocular administration. Luteolin, a potent anti-oxidant herbal drug with poor aqueous solubility, was complexe...

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Veröffentlicht in:	International journal of biological macromolecules 2024-01, Vol.254 (Pt 3), p.127930-127930, Article 127930
Hauptverfasser:	Omran, Sarah, Elnaggar, Yosra S R, Abdallah, Ossama Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use antioxidant activity antioxidants Antioxidants - therapeutic use chitosan Chitosan - therapeutic use Delayed-Action Preparations - pharmacology Delayed-Action Preparations - therapeutic use Drug Carriers - therapeutic use Drug Delivery Systems encapsulation glaucoma Glaucoma - drug therapy herbal medicines inflammation inhibitory concentration 50 lipophilicity luteolin Luteolin - pharmacology nanomaterials Nanoparticles Particle Size permeability pharmacodynamics phospholipids polarized light microscopy Rabbits solubility
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