Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT

Hypericum roeperianum is a medicinal spice traditionally used in West Africa to treat female sterility, fungal infections, and cancer. It has previously been reported that H. roeperianum exhibits cytotoxic potential by reducing the viability of cancer cells involving multidrug-resistant phenotypes,...

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Veröffentlicht in:	Journal of ethnopharmacology 2024-01, Vol.319, p.117093-117093, Article 117093
Hauptverfasser:	Guefack, Michel-Gael F., Talukdar, Debojit, Mukherjee, Rimi, Guha, Subhabrata, Mitra, Debarpan, Saha, Depanwita, Das, Gaurav, Damen, François, Kuete, Victor, Murmu, Nabendu
Format:	Artikel
Sprache:	eng
Schlagworte:	abortifacients Apoptosis bark extracts Breast cancer breast neoplasms cadherins cancer therapy caspase-9 cell cycle checkpoints cell movement cell viability cytochrome c cytotoxicity DNA damage DNA fragmentation EMT female fertility flow cytometry fungi Hypericum Hypericum roeperianum membrane potential mitochondria mitochondrial membrane mTOR multiple drug resistance neoplasm cells neoplasm progression phytochemicals quantitative polymerase chain reaction signal transduction spices toxicity testing traditional medicine vimentin Western Africa Western blotting
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