Fermented antler extract attenuates muscle atrophy by regulating the PI3K/Akt pathway and inflammatory response in immobilization-treated C57BL/6J mice
Muscle atrophy or muscle wasting, which is featured by reduced muscle function and mass, typically results from disuse, aging, and chronic diseases. The deer antler, which refers to the young and non-ossified antlers of various species of deer-related animals, is not fully calcified and comprises of...
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| Veröffentlicht in: | Food science and biotechnology 2024-12, Vol.33 (15), p.3617-3628 |
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| creator | Yoo, Jihee Kim, Changhee Lee, Hyerin Ko, Bong Soo Lee, Dong-Woo Hwang, Jae-Kwan |
| description | Muscle atrophy or muscle wasting, which is featured by reduced muscle function and mass, typically results from disuse, aging, and chronic diseases. The deer antler, which refers to the young and non-ossified antlers of various species of deer-related animals, is not fully calcified and comprises of densely growing hair. Here, we investigated whether
Bacillus subtilis
-fermented antler extract (FAE) inhibits immobilization-induced muscle atrophy in C57BL/6J mice. Oral administration of FAE increased grip strength, exercise performance, muscle mass, and volume in mice. FAE stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, enhancing the mammalian target of rapamycin pathway for muscle synthesis. FAE phosphorylated Forkhead box O3 and downregulated muscle RING finger-1 and atrogin-1 for proteolysis. FAE inhibited the mRNA expression of tumor necrosis factor alpha and interleukin-6 through nuclear factor kappa B. Consequently, FAE attenuated muscle atrophy by regulating the PI3K/Akt pathway and inflammation. |
| doi_str_mv | 10.1007/s10068-024-01606-z |
| format | Article |
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Bacillus subtilis
-fermented antler extract (FAE) inhibits immobilization-induced muscle atrophy in C57BL/6J mice. Oral administration of FAE increased grip strength, exercise performance, muscle mass, and volume in mice. FAE stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, enhancing the mammalian target of rapamycin pathway for muscle synthesis. FAE phosphorylated Forkhead box O3 and downregulated muscle RING finger-1 and atrogin-1 for proteolysis. FAE inhibited the mRNA expression of tumor necrosis factor alpha and interleukin-6 through nuclear factor kappa B. Consequently, FAE attenuated muscle atrophy by regulating the PI3K/Akt pathway and inflammation.</description><identifier>ISSN: 1226-7708</identifier><identifier>ISSN: 2092-6456</identifier><identifier>EISSN: 2092-6456</identifier><identifier>DOI: 10.1007/s10068-024-01606-z</identifier><identifier>PMID: 39493393</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Antlers ; athletic performance ; Atrophy ; Chemistry ; Chemistry and Materials Science ; deer ; fermentation ; Fingers ; Food Science ; Forkhead protein ; Gene expression ; Grip strength ; Immobilization ; Inflammation ; Inflammatory response ; Interleukin 6 ; Kinases ; muscle strength ; muscle tissues ; Muscles ; muscular atrophy ; Nutrition ; Oral administration ; phosphatidylinositol 3-kinase ; Proteolysis ; Rapamycin ; Research Article ; species ; TOR protein ; transcription factor NF-kappa B ; tumor necrosis factor-alpha</subject><ispartof>Food science and biotechnology, 2024-12, Vol.33 (15), p.3617-3628</ispartof><rights>The Korean Society of Food Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-34d65c6142c28d6355bbcb8266fcfc52d373c96e1037d62b3cae1475994ab493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10068-024-01606-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10068-024-01606-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39493393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Jihee</creatorcontrib><creatorcontrib>Kim, Changhee</creatorcontrib><creatorcontrib>Lee, Hyerin</creatorcontrib><creatorcontrib>Ko, Bong Soo</creatorcontrib><creatorcontrib>Lee, Dong-Woo</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><title>Fermented antler extract attenuates muscle atrophy by regulating the PI3K/Akt pathway and inflammatory response in immobilization-treated C57BL/6J mice</title><title>Food science and biotechnology</title><addtitle>Food Sci Biotechnol</addtitle><addtitle>Food Sci Biotechnol</addtitle><description>Muscle atrophy or muscle wasting, which is featured by reduced muscle function and mass, typically results from disuse, aging, and chronic diseases. The deer antler, which refers to the young and non-ossified antlers of various species of deer-related animals, is not fully calcified and comprises of densely growing hair. Here, we investigated whether
Bacillus subtilis
-fermented antler extract (FAE) inhibits immobilization-induced muscle atrophy in C57BL/6J mice. Oral administration of FAE increased grip strength, exercise performance, muscle mass, and volume in mice. FAE stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, enhancing the mammalian target of rapamycin pathway for muscle synthesis. FAE phosphorylated Forkhead box O3 and downregulated muscle RING finger-1 and atrogin-1 for proteolysis. FAE inhibited the mRNA expression of tumor necrosis factor alpha and interleukin-6 through nuclear factor kappa B. Consequently, FAE attenuated muscle atrophy by regulating the PI3K/Akt pathway and inflammation.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Antlers</subject><subject>athletic performance</subject><subject>Atrophy</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>deer</subject><subject>fermentation</subject><subject>Fingers</subject><subject>Food Science</subject><subject>Forkhead protein</subject><subject>Gene expression</subject><subject>Grip strength</subject><subject>Immobilization</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Interleukin 6</subject><subject>Kinases</subject><subject>muscle strength</subject><subject>muscle tissues</subject><subject>Muscles</subject><subject>muscular atrophy</subject><subject>Nutrition</subject><subject>Oral administration</subject><subject>phosphatidylinositol 3-kinase</subject><subject>Proteolysis</subject><subject>Rapamycin</subject><subject>Research Article</subject><subject>species</subject><subject>TOR protein</subject><subject>transcription factor NF-kappa B</subject><subject>tumor necrosis factor-alpha</subject><issn>1226-7708</issn><issn>2092-6456</issn><issn>2092-6456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAURi0EotPCC7BAltiwCeOf2E6WZURpYSRYdB85zs1MSmwH21GZeRFeF4cpILFAbGz5-txzZX8IvaDkDSVErWNeZVUQVhaESiKL4yO0YqRmhSyFfIxWlDFZKEWqM3Qe412mKVPlU3TG67LmvOYr9P0KggWXoMPapREChm8paJOwTgncrBNEbOdoRsiV4Kf9AbcHHGA3jzoNbofTHvDnG_5xffkl4Umn_b0-ZFeHB9eP2lqdfFga4uRdhFzFg7W-HcbhmAXeFSmAXuZvhHq7XcsP2A4GnqEnvR4jPH_YL9Dt1bvbzXWx_fT-ZnO5LQyr6lTwspPCSFqyfO4kF6JtTVsxKXvTG8E6rripJVDCVSdZy40GWipR16Vu8x9coNcn7RT81xliauwQDYyjduDn2HAqSqqoVOI_UMYrUjGmMvrqL_TOz8HldywUk4QLvgjZiTLBxxigb6YwWB0ODSXNEnBzCrjJATc_A26Ouenlg3puLXS_W34lmgF-AmK-cjsIf2b_Q_sDihuyNw</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Yoo, Jihee</creator><creator>Kim, Changhee</creator><creator>Lee, Hyerin</creator><creator>Ko, Bong Soo</creator><creator>Lee, Dong-Woo</creator><creator>Hwang, Jae-Kwan</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241201</creationdate><title>Fermented antler extract attenuates muscle atrophy by regulating the PI3K/Akt pathway and inflammatory response in immobilization-treated C57BL/6J mice</title><author>Yoo, Jihee ; Kim, Changhee ; Lee, Hyerin ; Ko, Bong Soo ; Lee, Dong-Woo ; Hwang, Jae-Kwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-34d65c6142c28d6355bbcb8266fcfc52d373c96e1037d62b3cae1475994ab493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Antlers</topic><topic>athletic performance</topic><topic>Atrophy</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>deer</topic><topic>fermentation</topic><topic>Fingers</topic><topic>Food Science</topic><topic>Forkhead protein</topic><topic>Gene expression</topic><topic>Grip strength</topic><topic>Immobilization</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Interleukin 6</topic><topic>Kinases</topic><topic>muscle strength</topic><topic>muscle tissues</topic><topic>Muscles</topic><topic>muscular atrophy</topic><topic>Nutrition</topic><topic>Oral administration</topic><topic>phosphatidylinositol 3-kinase</topic><topic>Proteolysis</topic><topic>Rapamycin</topic><topic>Research Article</topic><topic>species</topic><topic>TOR protein</topic><topic>transcription factor NF-kappa B</topic><topic>tumor necrosis factor-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Jihee</creatorcontrib><creatorcontrib>Kim, Changhee</creatorcontrib><creatorcontrib>Lee, Hyerin</creatorcontrib><creatorcontrib>Ko, Bong Soo</creatorcontrib><creatorcontrib>Lee, Dong-Woo</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Food science and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Jihee</au><au>Kim, Changhee</au><au>Lee, Hyerin</au><au>Ko, Bong Soo</au><au>Lee, Dong-Woo</au><au>Hwang, Jae-Kwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fermented antler extract attenuates muscle atrophy by regulating the PI3K/Akt pathway and inflammatory response in immobilization-treated C57BL/6J mice</atitle><jtitle>Food science and biotechnology</jtitle><stitle>Food Sci Biotechnol</stitle><addtitle>Food Sci Biotechnol</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>33</volume><issue>15</issue><spage>3617</spage><epage>3628</epage><pages>3617-3628</pages><issn>1226-7708</issn><issn>2092-6456</issn><eissn>2092-6456</eissn><abstract>Muscle atrophy or muscle wasting, which is featured by reduced muscle function and mass, typically results from disuse, aging, and chronic diseases. The deer antler, which refers to the young and non-ossified antlers of various species of deer-related animals, is not fully calcified and comprises of densely growing hair. Here, we investigated whether
Bacillus subtilis
-fermented antler extract (FAE) inhibits immobilization-induced muscle atrophy in C57BL/6J mice. Oral administration of FAE increased grip strength, exercise performance, muscle mass, and volume in mice. FAE stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, enhancing the mammalian target of rapamycin pathway for muscle synthesis. FAE phosphorylated Forkhead box O3 and downregulated muscle RING finger-1 and atrogin-1 for proteolysis. FAE inhibited the mRNA expression of tumor necrosis factor alpha and interleukin-6 through nuclear factor kappa B. Consequently, FAE attenuated muscle atrophy by regulating the PI3K/Akt pathway and inflammation.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>39493393</pmid><doi>10.1007/s10068-024-01606-z</doi><tpages>12</tpages></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Antlers athletic performance Atrophy Chemistry Chemistry and Materials Science deer fermentation Fingers Food Science Forkhead protein Gene expression Grip strength Immobilization Inflammation Inflammatory response Interleukin 6 Kinases muscle strength muscle tissues Muscles muscular atrophy Nutrition Oral administration phosphatidylinositol 3-kinase Proteolysis Rapamycin Research Article species TOR protein transcription factor NF-kappa B tumor necrosis factor-alpha |
| title | Fermented antler extract attenuates muscle atrophy by regulating the PI3K/Akt pathway and inflammatory response in immobilization-treated C57BL/6J mice |
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