ER stress aggravates NOD1-mediated inflammatory response leading to impaired nutrient metabolism in hepatoma cells

Nucleotide-binding Oligomerization Domain 1 (NOD1) is a cytosolic pattern recognition receptor that senses specific bacterial peptidoglycan moieties, leading to the induction of inflammatory response. Besides, sensing peptidoglycan, NOD1 has been reported to sense metabolic disturbances including th...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-11, Vol.735, p.150827, Article 150827
Hauptverfasser:	Gulzar, Farah, Chhikara, Nikita, Kumar, Pawan, Ahmad, Shadab, Yadav, Shubhi, Gayen, Jiaur R., Tamrakar, Akhilesh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	biochemical pathways calcium Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology domain eIF-2 Kinase - metabolism endoplasmic reticulum Endoplasmic Reticulum Stress Endoribonucleases - metabolism ER stress Gluconeogenesis glucose Glucose - metabolism Hep G2 Cells Hepatic homeostasis hepatoma Humans Inflammation Inflammation - metabolism Inflammation - pathology ligands lipids liver Liver Neoplasms - metabolism Liver Neoplasms - pathology NOD Nod1 Signaling Adaptor Protein - metabolism Nutrient metabolism Nutrients - metabolism oligomerization Peptidoglycan - metabolism peptidoglycans protein kinases Protein Serine-Threonine Kinases - metabolism Thapsigargin - pharmacology Unfolded Protein Response
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