Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells
Currently, the supply of beta cells for islet transplantation in the treatment of type 1 diabetes is limited. Enteroendocrine cells (EECs) are believed to have high potential as stem cells because they share significant developmental similarities with beta cells. In a previous study, we derived EEC...
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| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2024-10, Vol.60 (9), p.1099-1108 |
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| creator | Ryu, Gyeong Ryul Bae, Dongryeoul Uddin, Shahab Meah, Mohammed Sohel Ahmad, Waqas Silvano, Kris John Ahn, Gyeongik Cha, Joon-Yung Lee, Esder Song, Ki-Ho Kim, Woe-Yeon Kim, Min Gab |
| description | Currently, the supply of beta cells for islet transplantation in the treatment of type 1 diabetes is limited. Enteroendocrine cells (EECs) are believed to have high potential as stem cells because they share significant developmental similarities with beta cells. In a previous study, we derived EEC cells that secrete individual gut hormones from STC-1 cells. This study aimed to examine intestinal hormone secretion and expression, investigate the expression of developmental-related transcription factors, and analyze the effect of MEOX on
insulin
gene expression in isolated EECs. The expression and secretion of enteroendocrine hormones were evaluated in L6 and K34 cells from STC-1 cells. Expression patterns of beta cell- and development-related genes in L6 and K34 cells were compared with beta cells. Comparisons of the MEOX-induced expression of
Ins
in beta cells and GLP-1-secreting cells were investigated. Both L6 and K34 cells predominantly expressed
Glp1
and
Gip
, respectively. The secretion pattern of GLP-1 in L6 cells was similar to that of GLUTag cells. Previous microarray analysis confirmed MEOX as developmentally relevant transcription factors expressed in beta cells. Overexpression of MEOX showed a tendency to increase
Ins
expression in L6 and GLUTag cells, but not in MIN6 cells. However, when PDX1 and MEOX were co-expressed in GLUTag cells,
insulin
expression was suppressed, similar to that observed in MIN6 cells. These findings suggest a potential role for MEOX in regulating the expression of the
Ins
gene in both beta cells and GLP-1-secreting cells. Further studies are warranted to elucidate the underlying mechanism. |
| doi_str_mv | 10.1007/s11626-024-00964-6 |
| format | Article |
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insulin
gene expression in isolated EECs. The expression and secretion of enteroendocrine hormones were evaluated in L6 and K34 cells from STC-1 cells. Expression patterns of beta cell- and development-related genes in L6 and K34 cells were compared with beta cells. Comparisons of the MEOX-induced expression of
Ins
in beta cells and GLP-1-secreting cells were investigated. Both L6 and K34 cells predominantly expressed
Glp1
and
Gip
, respectively. The secretion pattern of GLP-1 in L6 cells was similar to that of GLUTag cells. Previous microarray analysis confirmed MEOX as developmentally relevant transcription factors expressed in beta cells. Overexpression of MEOX showed a tendency to increase
Ins
expression in L6 and GLUTag cells, but not in MIN6 cells. However, when PDX1 and MEOX were co-expressed in GLUTag cells,
insulin
expression was suppressed, similar to that observed in MIN6 cells. These findings suggest a potential role for MEOX in regulating the expression of the
Ins
gene in both beta cells and GLP-1-secreting cells. Further studies are warranted to elucidate the underlying mechanism.</description><identifier>ISSN: 1071-2690</identifier><identifier>ISSN: 1543-706X</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-024-00964-6</identifier><identifier>PMID: 39138833</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal Genetics and Genomics ; Animals ; Beta cells ; Biomedical and Life Sciences ; Cell Biology ; Cell Culture ; Cell Line ; Developmental Biology ; Diabetes mellitus (insulin dependent) ; DNA microarrays ; Enteroendocrine Cells - metabolism ; Gene expression ; Gene Expression Regulation ; genes ; Glucagon ; Glucagon-like peptide 1 ; Glucagon-Like Peptide 1 - genetics ; Glucagon-Like Peptide 1 - metabolism ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; hormone secretion ; Hormones ; INS gene ; Insulin ; Insulin - genetics ; Insulin - metabolism ; insulin-dependent diabetes mellitus ; Insulin-Secreting Cells - metabolism ; intestines ; Islet cells ; Life Sciences ; Mice ; microarray technology ; Pancreas ; Pancreatic islet transplantation ; Pattern analysis ; Rats ; Secretion ; Stem Cells ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>In vitro cellular & developmental biology. Animal, 2024-10, Vol.60 (9), p.1099-1108</ispartof><rights>The Society for In Vitro Biology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Society for In Vitro Biology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-7af440de3ad3aca79bbe39f83323c2afa2171c6b6283b0e9ff5d50bd3b6d8f413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11626-024-00964-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11626-024-00964-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39138833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Gyeong Ryul</creatorcontrib><creatorcontrib>Bae, Dongryeoul</creatorcontrib><creatorcontrib>Uddin, Shahab</creatorcontrib><creatorcontrib>Meah, Mohammed Sohel</creatorcontrib><creatorcontrib>Ahmad, Waqas</creatorcontrib><creatorcontrib>Silvano, Kris John</creatorcontrib><creatorcontrib>Ahn, Gyeongik</creatorcontrib><creatorcontrib>Cha, Joon-Yung</creatorcontrib><creatorcontrib>Lee, Esder</creatorcontrib><creatorcontrib>Song, Ki-Ho</creatorcontrib><creatorcontrib>Kim, Woe-Yeon</creatorcontrib><creatorcontrib>Kim, Min Gab</creatorcontrib><title>Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>Currently, the supply of beta cells for islet transplantation in the treatment of type 1 diabetes is limited. Enteroendocrine cells (EECs) are believed to have high potential as stem cells because they share significant developmental similarities with beta cells. In a previous study, we derived EEC cells that secrete individual gut hormones from STC-1 cells. This study aimed to examine intestinal hormone secretion and expression, investigate the expression of developmental-related transcription factors, and analyze the effect of MEOX on
insulin
gene expression in isolated EECs. The expression and secretion of enteroendocrine hormones were evaluated in L6 and K34 cells from STC-1 cells. Expression patterns of beta cell- and development-related genes in L6 and K34 cells were compared with beta cells. Comparisons of the MEOX-induced expression of
Ins
in beta cells and GLP-1-secreting cells were investigated. Both L6 and K34 cells predominantly expressed
Glp1
and
Gip
, respectively. The secretion pattern of GLP-1 in L6 cells was similar to that of GLUTag cells. Previous microarray analysis confirmed MEOX as developmentally relevant transcription factors expressed in beta cells. Overexpression of MEOX showed a tendency to increase
Ins
expression in L6 and GLUTag cells, but not in MIN6 cells. However, when PDX1 and MEOX were co-expressed in GLUTag cells,
insulin
expression was suppressed, similar to that observed in MIN6 cells. These findings suggest a potential role for MEOX in regulating the expression of the
Ins
gene in both beta cells and GLP-1-secreting cells. Further studies are warranted to elucidate the underlying mechanism.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Beta cells</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell Line</subject><subject>Developmental Biology</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>DNA microarrays</subject><subject>Enteroendocrine Cells - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>genes</subject><subject>Glucagon</subject><subject>Glucagon-like peptide 1</subject><subject>Glucagon-Like Peptide 1 - genetics</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>hormone secretion</subject><subject>Hormones</subject><subject>INS gene</subject><subject>Insulin</subject><subject>Insulin - genetics</subject><subject>Insulin - metabolism</subject><subject>insulin-dependent diabetes mellitus</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>intestines</subject><subject>Islet cells</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>microarray technology</subject><subject>Pancreas</subject><subject>Pancreatic islet transplantation</subject><subject>Pattern analysis</subject><subject>Rats</subject><subject>Secretion</subject><subject>Stem Cells</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1071-2690</issn><issn>1543-706X</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFSEUxYnR2PbVL-DCkLhxg73APBiWpnlqkzbd2KQ7wjCXCXUeM8JMot9eXl_VxIWy4d_vHg73EPKaw3sOoC8K50ooBqJhAEY1TD0jp3zbSKZB3T-va9CcCWXghJyV8gB1GK5ekhNpuGxbKU9J3IWAfqFToEt2qfgc5yVOiQbnlynTm93tPa3bmMo6xkQHTEjx-5yxlPh4Todx9W6YEhvjV6Qz1voeKWcFfcYlpoF6HMdyTl4ENxZ89TRvyN3H3ZfLz-z69tPV5Ydr5kVrFqZdaBroUbpeOu-06TqUJlSzQnrhghNcc686JVrZAZoQtv0Wul52qm9Dw-WGvDvqznn6tmJZ7D6WgwOXcFqLlbVDXMNWqv-jYESr4dCpDXn7F_owrTnVj1RB0XDgUuhKiSPl81RKxmDnHPcu_7Ac7CEze8zM1szsY2b24OLNk_Ta7bH_XfIrpArII1DqVRow_3n7H7I_ARsvofE</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Ryu, Gyeong Ryul</creator><creator>Bae, Dongryeoul</creator><creator>Uddin, Shahab</creator><creator>Meah, Mohammed Sohel</creator><creator>Ahmad, Waqas</creator><creator>Silvano, Kris John</creator><creator>Ahn, Gyeongik</creator><creator>Cha, Joon-Yung</creator><creator>Lee, Esder</creator><creator>Song, Ki-Ho</creator><creator>Kim, Woe-Yeon</creator><creator>Kim, Min Gab</creator><general>Springer US</general><general>Society for In Vitro Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241001</creationdate><title>Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells</title><author>Ryu, Gyeong Ryul ; Bae, Dongryeoul ; Uddin, Shahab ; Meah, Mohammed Sohel ; Ahmad, Waqas ; Silvano, Kris John ; Ahn, Gyeongik ; Cha, Joon-Yung ; Lee, Esder ; Song, Ki-Ho ; Kim, Woe-Yeon ; Kim, Min Gab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-7af440de3ad3aca79bbe39f83323c2afa2171c6b6283b0e9ff5d50bd3b6d8f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Beta cells</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell Line</topic><topic>Developmental Biology</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>DNA microarrays</topic><topic>Enteroendocrine Cells - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>genes</topic><topic>Glucagon</topic><topic>Glucagon-like peptide 1</topic><topic>Glucagon-Like Peptide 1 - genetics</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>hormone secretion</topic><topic>Hormones</topic><topic>INS gene</topic><topic>Insulin</topic><topic>Insulin - genetics</topic><topic>Insulin - metabolism</topic><topic>insulin-dependent diabetes mellitus</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>intestines</topic><topic>Islet cells</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>microarray technology</topic><topic>Pancreas</topic><topic>Pancreatic islet transplantation</topic><topic>Pattern analysis</topic><topic>Rats</topic><topic>Secretion</topic><topic>Stem Cells</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Gyeong Ryul</creatorcontrib><creatorcontrib>Bae, Dongryeoul</creatorcontrib><creatorcontrib>Uddin, Shahab</creatorcontrib><creatorcontrib>Meah, Mohammed Sohel</creatorcontrib><creatorcontrib>Ahmad, Waqas</creatorcontrib><creatorcontrib>Silvano, Kris John</creatorcontrib><creatorcontrib>Ahn, Gyeongik</creatorcontrib><creatorcontrib>Cha, Joon-Yung</creatorcontrib><creatorcontrib>Lee, Esder</creatorcontrib><creatorcontrib>Song, Ki-Ho</creatorcontrib><creatorcontrib>Kim, Woe-Yeon</creatorcontrib><creatorcontrib>Kim, Min Gab</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>In vitro cellular & developmental biology. 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Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>60</volume><issue>9</issue><spage>1099</spage><epage>1108</epage><pages>1099-1108</pages><issn>1071-2690</issn><issn>1543-706X</issn><eissn>1543-706X</eissn><abstract>Currently, the supply of beta cells for islet transplantation in the treatment of type 1 diabetes is limited. Enteroendocrine cells (EECs) are believed to have high potential as stem cells because they share significant developmental similarities with beta cells. In a previous study, we derived EEC cells that secrete individual gut hormones from STC-1 cells. This study aimed to examine intestinal hormone secretion and expression, investigate the expression of developmental-related transcription factors, and analyze the effect of MEOX on
insulin
gene expression in isolated EECs. The expression and secretion of enteroendocrine hormones were evaluated in L6 and K34 cells from STC-1 cells. Expression patterns of beta cell- and development-related genes in L6 and K34 cells were compared with beta cells. Comparisons of the MEOX-induced expression of
Ins
in beta cells and GLP-1-secreting cells were investigated. Both L6 and K34 cells predominantly expressed
Glp1
and
Gip
, respectively. The secretion pattern of GLP-1 in L6 cells was similar to that of GLUTag cells. Previous microarray analysis confirmed MEOX as developmentally relevant transcription factors expressed in beta cells. Overexpression of MEOX showed a tendency to increase
Ins
expression in L6 and GLUTag cells, but not in MIN6 cells. However, when PDX1 and MEOX were co-expressed in GLUTag cells,
insulin
expression was suppressed, similar to that observed in MIN6 cells. These findings suggest a potential role for MEOX in regulating the expression of the
Ins
gene in both beta cells and GLP-1-secreting cells. Further studies are warranted to elucidate the underlying mechanism.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39138833</pmid><doi>10.1007/s11626-024-00964-6</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal Genetics and Genomics Animals Beta cells Biomedical and Life Sciences Cell Biology Cell Culture Cell Line Developmental Biology Diabetes mellitus (insulin dependent) DNA microarrays Enteroendocrine Cells - metabolism Gene expression Gene Expression Regulation genes Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - genetics Glucagon-Like Peptide 1 - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism hormone secretion Hormones INS gene Insulin Insulin - genetics Insulin - metabolism insulin-dependent diabetes mellitus Insulin-Secreting Cells - metabolism intestines Islet cells Life Sciences Mice microarray technology Pancreas Pancreatic islet transplantation Pattern analysis Rats Secretion Stem Cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism |
| title | Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells |
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