Safe plant Hsp90 adjuvants elicit an effective immune response against SARS-CoV2-derived RBD antigen

To better understand the role of pHsp90 adjuvant in immune response modulation, we proposed the use of the Receptor Binding Domain (RBD) of the Spike protein of SARS-CoV2, the principal candidate in the design of subunit vaccines. We evaluated the humoral and cellular immune responses against RBD th...

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Veröffentlicht in:	Vaccine 2024-05, Vol.42 (14), p.3355-3364
Hauptverfasser:	Ramos-Duarte, Victor A., Orlowski, Alejandro, Jaquenod de Giusti, Carolina, Corigliano, Mariana G., Legarralde, Ariel, Mendoza-Morales, Luisa F., Atela, Agustín, Sánchez, Manuel A., Sander, Valeria A., Angel, Sergio O., Clemente, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Antibodies Antigens cell-mediated immunity COVID-19 vaccines Cytokines domain Hsp90 protein Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunization Immunoglobulin G Immunomodulation Immunoprecipitation Infectious diseases interleukin-4 Laboratory animals Neutralizing Pandemics Pathogens Peptides Plant Hsp90 Plasmids precipitin tests Proteins RBD SARS-CoV2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Spleen subunit vaccines Vaccines Viral infections γ-Interferon
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