EGCG attenuated acute myocardial infarction by inhibiting ferroptosis via miR-450b-5p/ACSL4 axis

Epigallocatechin gallate (EGCG) has multiple biological effects such as anti-tumor multiple drug resistance, antioxidation and anti-inflammatory properties. Ferroptosis is the main driving factor of ischemic heart injury, thus inhibiting ferroptosis may prove to be an effective treatment strategy fo...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-10, Vol.119, p.154999-154999, Article 154999
Hauptverfasser:	Yu, Qiuting, Zhang, Ning, Gan, Xiaowen, Chen, Linglin, Wang, Rui, Liang, Ronggan, Jian, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myocardial infarction Acyl-CoA synthetase long-chain family member 4 cardiomyocytes cardioprotective effect cell viability echocardiography eosin Epigallocatechin gallate Ferroptosis flow cytometry glutathione hypoxia infarction lipid peroxidation luciferase malondialdehyde miR-450b-5p/ACSL4 axis multiple drug resistance myocardial infarction plasmids reactive oxygen species superoxide dismutase therapeutics transmission electron microscopy
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