Nano-delivery Systems and Therapeutic Applications of Phytodrug Mangiferin
In order to cure a range of ailments, scientists have investigated a number of bioactive antioxidant compounds produced from natural sources. Mangiferin, a C-glycosyl xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effec...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2024-10, Vol.196 (10), p.7429-7463 |
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| creator | Baghel, Madhuri Baghel, Ishita Kumari, Pramila Bharkatiya, Meenakshi Joshi, Garvita Sakure, Kalyani Badwaik, Hemant |
| description | In order to cure a range of ailments, scientists have investigated a number of bioactive antioxidant compounds produced from natural sources. Mangiferin, a C-glycosyl xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effective in the treatment of a variety of disorders due to its antiviral, anti-inflammatory, antiproliferative, antigenotoxic, antiatherogenic, radioprotective, nephroprotective, antihyperlipidemic, and antidiabetic properties. However, it is recognised that mangiferin’s poor bioavailability, volatility, and limited solubility restrict its therapeutic usefulness. Over time, effective solutions to these problems have arisen in the shape of effective delivery methods. The current articles present a summary of the several researches that have updated Mangiferin’s biopharmaceutical characteristics. Additionally, strategies for enhancing the bioavailability, stability, and solubility of this phytodrug have been discussed. This review provides detailed information on the development of innovative Mangiferin delivery methods such as nanoparticles, liposomes, micelles, niosomes, microspheres, metal nanoparticles, and complexation, as well as its therapeutic applications in a variety of sectors. This article provides effective guidance for researchers who desire to work on the formulation and development of an effective delivery method for improved magniferin therapeutic effectiveness. |
| doi_str_mv | 10.1007/s12010-024-04906-6 |
| format | Article |
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Mangiferin, a C-glycosyl xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effective in the treatment of a variety of disorders due to its antiviral, anti-inflammatory, antiproliferative, antigenotoxic, antiatherogenic, radioprotective, nephroprotective, antihyperlipidemic, and antidiabetic properties. However, it is recognised that mangiferin’s poor bioavailability, volatility, and limited solubility restrict its therapeutic usefulness. Over time, effective solutions to these problems have arisen in the shape of effective delivery methods. The current articles present a summary of the several researches that have updated Mangiferin’s biopharmaceutical characteristics. Additionally, strategies for enhancing the bioavailability, stability, and solubility of this phytodrug have been discussed. This review provides detailed information on the development of innovative Mangiferin delivery methods such as nanoparticles, liposomes, micelles, niosomes, microspheres, metal nanoparticles, and complexation, as well as its therapeutic applications in a variety of sectors. 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This review provides detailed information on the development of innovative Mangiferin delivery methods such as nanoparticles, liposomes, micelles, niosomes, microspheres, metal nanoparticles, and complexation, as well as its therapeutic applications in a variety of sectors. 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| subjects | Animals antioxidants Bioavailability Biochemistry Biological Availability Biotechnology Chemistry Chemistry and Materials Science Diabetes mellitus Drug Delivery Systems Effectiveness Humans Liposomes - chemistry Micelles microparticles Microspheres Nanoparticle Drug Delivery System - chemistry Nanoparticles Nanoparticles - chemistry nephroprotective effect niosomes Original Article Pharmacology polyphenols Solubility Therapeutic applications therapeutics Xanthones - chemistry Xanthones - pharmacokinetics |
| title | Nano-delivery Systems and Therapeutic Applications of Phytodrug Mangiferin |
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