Embedded Bioprinting of Tumor-Scale Pancreatic Cancer-Stroma 3D Models for Preclinical Drug Screening

The establishment of organotypic preclinical models that accurately resemble the native tumor microenvironment at an anatomic human scale is highly desirable to level up in vitro platforms potential for screening candidate therapies. The bioengineering of anatomic-scaled three-dimensional (3D) model...

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Veröffentlicht in:	ACS applied materials & interfaces 2024-10, Vol.16 (42), p.56718-56729
Hauptverfasser:	Monteiro, Maria V., Rocha, Marta, Carvalho, Mariana T., Freitas, Inês, Amaral, Adérito J. R., Sousa, Filipa L., Gaspar, Vítor M., Mano, João F.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology biocompatible materials biofabrication Biological and Medical Applications of Materials and Interfaces Bioprinting Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - pharmacology dose response Drug Evaluation, Preclinical drug resistance Drug Screening Assays, Antitumor drug therapy drugs extracellular matrix Extracellular Matrix - chemistry Extracellular Matrix - drug effects Extracellular Matrix - metabolism fibroblasts Gelatin - chemistry Gemcitabine Humans hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology light Methacrylates - chemistry pancreatic neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology polymers Printing, Three-Dimensional Stromal Cells - drug effects Stromal Cells - pathology Tumor Microenvironment - drug effects viscoelasticity
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