Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis
Cancer derived exosomal biomarkers (e.g. proteins, RNAs) could reflect important information about the cancer microenvironment. For ultrasensitive analysis of exosomal biomarkers, surface-enhanced Raman scattering (SERS) is one of the primary methods. Regarding the specific requirement of exosomal a...
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| Veröffentlicht in: | TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2023-10, Vol.167, p.117253, Article 117253 |
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| container_title | TrAC, Trends in analytical chemistry (Regular ed.) |
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| creator | Tan, Hong-Sheng Wang, Tong Sun, He-Nan Liu, Aihua Li, Shan-Shan |
| description | Cancer derived exosomal biomarkers (e.g. proteins, RNAs) could reflect important information about the cancer microenvironment. For ultrasensitive analysis of exosomal biomarkers, surface-enhanced Raman scattering (SERS) is one of the primary methods. Regarding the specific requirement of exosomal analysis, we firstly summarized the SERS substrates from zero-dimensional (0D) colloidal substrates to 2D planar substrates, and 3D stereoscopic substrates in the past five years. In terms of exosomal biomarkers analysis, we systematically subdivided label-free and label-aid SERS analysis into exosome, exosomal protein, and exosomal miRNA detection, according to the actual detection targets. Ultimately, we made a brief summary of the overview and look forward to the forthcoming directions of SERS-based exosomal analysis. This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS, and shed light on the important status of exosomes in the early diagnosis of cancer.
[Display omitted]
•SERS substrates were summarized including 0D colloidal substrates, 2D planar substrates, and 3D stereoscopic substrates.•The label-free and label-aid analysis were classified into exosome, exosomal protein, and exosomal miRNA detection.•This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS. |
| doi_str_mv | 10.1016/j.trac.2023.117253 |
| format | Article |
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[Display omitted]
•SERS substrates were summarized including 0D colloidal substrates, 2D planar substrates, and 3D stereoscopic substrates.•The label-free and label-aid analysis were classified into exosome, exosomal protein, and exosomal miRNA detection.•This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS.</description><identifier>ISSN: 0165-9936</identifier><identifier>EISSN: 1879-3142</identifier><identifier>DOI: 10.1016/j.trac.2023.117253</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>analytical chemistry ; biomarkers ; early diagnosis ; Exosomal miRNA ; Exosomal protein ; Exosome ; exosomes ; Label-aid ; Label-free ; microRNA ; Raman spectroscopy ; SERS substrate</subject><ispartof>TrAC, Trends in analytical chemistry (Regular ed.), 2023-10, Vol.167, p.117253, Article 117253</ispartof><rights>2023 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-43e9f6c388ee097043aaeaa42ff48debff626bfb3e5671bc69361d0d4fec6e7d3</citedby><cites>FETCH-LOGICAL-c333t-43e9f6c388ee097043aaeaa42ff48debff626bfb3e5671bc69361d0d4fec6e7d3</cites><orcidid>0000-0003-1426-1167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165993623003400$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Tan, Hong-Sheng</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Sun, He-Nan</creatorcontrib><creatorcontrib>Liu, Aihua</creatorcontrib><creatorcontrib>Li, Shan-Shan</creatorcontrib><title>Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis</title><title>TrAC, Trends in analytical chemistry (Regular ed.)</title><description>Cancer derived exosomal biomarkers (e.g. proteins, RNAs) could reflect important information about the cancer microenvironment. For ultrasensitive analysis of exosomal biomarkers, surface-enhanced Raman scattering (SERS) is one of the primary methods. Regarding the specific requirement of exosomal analysis, we firstly summarized the SERS substrates from zero-dimensional (0D) colloidal substrates to 2D planar substrates, and 3D stereoscopic substrates in the past five years. In terms of exosomal biomarkers analysis, we systematically subdivided label-free and label-aid SERS analysis into exosome, exosomal protein, and exosomal miRNA detection, according to the actual detection targets. Ultimately, we made a brief summary of the overview and look forward to the forthcoming directions of SERS-based exosomal analysis. This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS, and shed light on the important status of exosomes in the early diagnosis of cancer.
[Display omitted]
•SERS substrates were summarized including 0D colloidal substrates, 2D planar substrates, and 3D stereoscopic substrates.•The label-free and label-aid analysis were classified into exosome, exosomal protein, and exosomal miRNA detection.•This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS.</description><subject>analytical chemistry</subject><subject>biomarkers</subject><subject>early diagnosis</subject><subject>Exosomal miRNA</subject><subject>Exosomal protein</subject><subject>Exosome</subject><subject>exosomes</subject><subject>Label-aid</subject><subject>Label-free</subject><subject>microRNA</subject><subject>Raman spectroscopy</subject><subject>SERS substrate</subject><issn>0165-9936</issn><issn>1879-3142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAUxIMouK5-AU89emlNmjRtwcuy-A8WFkTPIU1fMGu3qXndxf32ptSzp4HHzGPmR8gtoxmjTN7vsjFok-U05xljZV7wM7JgVVmnnIn8nCyiqUjrmstLcoW4o5RKSusF2a7ao-4NYOJtgodgtYEU-s_p1iZveq_7BAcwY_Bo_HBKXJ_Aj0e_113SuCjhCwImutfdCR1ekwurO4SbP12Sj6fH9_VLutk-v65Xm9RwzsdUcKitNLyqAGhdUsG1Bq1Fbq2oWmislblsbMOhkCVrjIzNWUtbYcFIKFu-JHfz3yH47wPgqPYODXSd7sEfUHFWCCZLUdFozWeriRswgFVDcLH3STGqJnpqpyZ6aqKnZnox9DCHII44OggKjYMJiguRhmq9-y_-C107ek0</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Tan, Hong-Sheng</creator><creator>Wang, Tong</creator><creator>Sun, He-Nan</creator><creator>Liu, Aihua</creator><creator>Li, Shan-Shan</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-1426-1167</orcidid></search><sort><creationdate>202310</creationdate><title>Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis</title><author>Tan, Hong-Sheng ; Wang, Tong ; Sun, He-Nan ; Liu, Aihua ; Li, Shan-Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-43e9f6c388ee097043aaeaa42ff48debff626bfb3e5671bc69361d0d4fec6e7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>analytical chemistry</topic><topic>biomarkers</topic><topic>early diagnosis</topic><topic>Exosomal miRNA</topic><topic>Exosomal protein</topic><topic>Exosome</topic><topic>exosomes</topic><topic>Label-aid</topic><topic>Label-free</topic><topic>microRNA</topic><topic>Raman spectroscopy</topic><topic>SERS substrate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Hong-Sheng</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Sun, He-Nan</creatorcontrib><creatorcontrib>Liu, Aihua</creatorcontrib><creatorcontrib>Li, Shan-Shan</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Hong-Sheng</au><au>Wang, Tong</au><au>Sun, He-Nan</au><au>Liu, Aihua</au><au>Li, Shan-Shan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis</atitle><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle><date>2023-10</date><risdate>2023</risdate><volume>167</volume><spage>117253</spage><pages>117253-</pages><artnum>117253</artnum><issn>0165-9936</issn><eissn>1879-3142</eissn><abstract>Cancer derived exosomal biomarkers (e.g. proteins, RNAs) could reflect important information about the cancer microenvironment. For ultrasensitive analysis of exosomal biomarkers, surface-enhanced Raman scattering (SERS) is one of the primary methods. Regarding the specific requirement of exosomal analysis, we firstly summarized the SERS substrates from zero-dimensional (0D) colloidal substrates to 2D planar substrates, and 3D stereoscopic substrates in the past five years. In terms of exosomal biomarkers analysis, we systematically subdivided label-free and label-aid SERS analysis into exosome, exosomal protein, and exosomal miRNA detection, according to the actual detection targets. Ultimately, we made a brief summary of the overview and look forward to the forthcoming directions of SERS-based exosomal analysis. This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS, and shed light on the important status of exosomes in the early diagnosis of cancer.
[Display omitted]
•SERS substrates were summarized including 0D colloidal substrates, 2D planar substrates, and 3D stereoscopic substrates.•The label-free and label-aid analysis were classified into exosome, exosomal protein, and exosomal miRNA detection.•This review will attract researchers who dedicated to analysis of cancer derived exosomal biomarkers via SERS.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.trac.2023.117253</doi><orcidid>https://orcid.org/0000-0003-1426-1167</orcidid></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | analytical chemistry biomarkers early diagnosis Exosomal miRNA Exosomal protein Exosome exosomes Label-aid Label-free microRNA Raman spectroscopy SERS substrate |
| title | Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis |
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