Ablation of CCDC8 provides cardioprotection against cardiomyocyte apoptosis via TNF signaling pathway in myocardial ischemia reperfusion injury

Myocardial ischemia-reperfusion (I/R) injury induces significant apoptosis and reactive oxygen species (ROS) accumulation in cardiomyocytes. Coiled-coil domain-containing 8 (CCDC8), recently identified as an interacting protein of p53, acts as a cofactor in p53-mediated apoptosis. However, its role...

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Veröffentlicht in:	Life sciences (1973) 2024-12, Vol.358, p.123151, Article 123151
Hauptverfasser:	Huang, Jungang, Li, Zexiong, Huang, Weipeng, He, Junbing, Zheng, Junmeng, Jiang, Shaoru, Lin, Jun, Xu, Mingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cardiomyocyte apoptosis cardiomyocytes cardioprotective effect CCDC8 Humans Male Mice Mice, Inbred C57BL myocardial ischemia Myocardial ischemia reperfusion Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Rats Reactive oxygen species Reactive Oxygen Species - metabolism reperfusion injury RNA Signal Transduction therapeutics TNF signaling Tumor Necrosis Factor-alpha - metabolism
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