Autocrine/paracrine fibroblast growth factor 1 (FGF1) enhances systemic lipid metabolism in rainbow trout fed with a high-fat diet by elevating uridine levels through the AMPK signaling pathway and activating the upp2 promoter via irf1

Fibroblast growth factor 1 (FGF1) is recognized for its role in regulating vertebrate energy metabolism, yet its impact on metabolic fatty liver disease in fish remains unexamined. This study investigates the regulatory mechanism of the autocrine/paracrine cytokine FGF1 on systemic lipid metabolism...

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Veröffentlicht in:	Aquaculture 2025-02, Vol.596, p.741885, Article 741885
Hauptverfasser:	Yu, Huixia, Mo, Haolin, An, Xiaoran, Yao, Mingxing, Gao, Jiuwei, Yu, Jiajia, Xiong, Dongmei, Liu, Haixia, Li, Yang, Wang, Lixin
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPK pathway aquaculture autocrine signaling beta oxidation biosynthesis blood serum body weight catabolism crude fat cytokines energy metabolism fatty acids fatty liver Fibroblast growth factor 1 hepatosomatic index High-fat diet interferon regulatory factor-1 liver low fat diet metabolomics muscles Oncorhynchus mykiss phosphorylase Rainbow trout transcription (genetics) triacylglycerols Uridine vacuoles weight gain
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