Native Digestion and Shotgun Proteomics for Host Cell Protein Profiling of Adeno-Associated Viruses

Host cell proteins (HCPs) are contaminants of biotherapeutics produced from engineered living systems; they can influence the product’s quality, efficacy, and toxicity. Liquid chromatography coupled to mass spectrometry can detect HCPs thereby mitigating their risks. However, highly abundant biother...

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