Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl
Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases ca...
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| Veröffentlicht in: | Microbial pathogenesis 2024-12, Vol.197, p.107089, Article 107089 |
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| creator | Wang, Bing Tan, Huihui Sun, Xiuyun Lin, Zizi Chen, Xiayu Han, Hongguang Wang, Mingfang Wang, Zijie Chen, Xiangxiu Deng, Yinyue Song, Shihao |
| description | Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases caused by C. albicans. We screened moscatin, and assessed the inhibitory effectiveness against C. albicans SC5314 on hyphae production and biofilm formation. It was revealed that moscatin exhibited significant effects on morphological transition and biofilm formation in C. albicans SC5314. It also lowered the pathogenicity of C. albicans SC5314 in a concentration-dependent way in both A549 cells and mice fungal infection models, but had no cytotoxicity to A549 cells. In addition, moscatin attenuated the virulence of clinical fluconazole-resistant C. albicans and exhibited synergistic activity with fluconazole. It could also restore the composition and richness of the intestinal microbiota in mice infected by C. albicans. These findings indicate that these moscatin has great potential to be developed as a new therapeutic drug against C. albicans infection.
•Moscatin is a promising agent for the treatment of C. albicans infection.•Moscatin interferes with the cAMP-PKA and MAPK pathways in C. albicans.•Moscatin exhibited excellent activity against C. albicans SC5314 infection in vitro and in vivo.•Moscatin can enhance the effectiveness of antibiotics.•Moscatin can significantly improve the intestinal microflora in mice infection model. |
| doi_str_mv | 10.1016/j.micpath.2024.107089 |
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•Moscatin is a promising agent for the treatment of C. albicans infection.•Moscatin interferes with the cAMP-PKA and MAPK pathways in C. albicans.•Moscatin exhibited excellent activity against C. albicans SC5314 infection in vitro and in vivo.•Moscatin can enhance the effectiveness of antibiotics.•Moscatin can significantly improve the intestinal microflora in mice infection model.</description><identifier>ISSN: 0882-4010</identifier><identifier>ISSN: 1096-1208</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2024.107089</identifier><identifier>PMID: 39477034</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>A549 Cells ; Animals ; Antifungal Agents - pharmacology ; biofilm ; Biofilm formation ; Biofilms - drug effects ; Biofilms - growth & development ; Candida albicans ; Candida albicans - drug effects ; Candida albicans - pathogenicity ; Candidiasis - drug therapy ; Candidiasis - microbiology ; cytotoxicity ; Dendrobium - chemistry ; Dendrobium - microbiology ; Dendrobium nobile ; Disease Models, Animal ; drug resistance ; Drug Resistance, Fungal ; Drug Synergism ; fluconazole ; Fluconazole - pharmacology ; fungi ; Gastrointestinal Microbiome - drug effects ; Humans ; hyphae ; Hyphae - drug effects ; Hyphae - growth & development ; Hyphae formation ; intestinal microorganisms ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Moscatin ; pathogenesis ; Plant Extracts - pharmacology ; synergism ; therapeutics ; Virulence ; Virulence - drug effects</subject><ispartof>Microbial pathogenesis, 2024-12, Vol.197, p.107089, Article 107089</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-1588f9c72c291ae4681e0bff8dc462d2721475658af618668ee23c7596ec944b3</cites><orcidid>0000-0003-0258-4065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0882401024005564$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39477034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Tan, Huihui</creatorcontrib><creatorcontrib>Sun, Xiuyun</creatorcontrib><creatorcontrib>Lin, Zizi</creatorcontrib><creatorcontrib>Chen, Xiayu</creatorcontrib><creatorcontrib>Han, Hongguang</creatorcontrib><creatorcontrib>Wang, Mingfang</creatorcontrib><creatorcontrib>Wang, Zijie</creatorcontrib><creatorcontrib>Chen, Xiangxiu</creatorcontrib><creatorcontrib>Deng, Yinyue</creatorcontrib><creatorcontrib>Song, Shihao</creatorcontrib><title>Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases caused by C. albicans. We screened moscatin, and assessed the inhibitory effectiveness against C. albicans SC5314 on hyphae production and biofilm formation. It was revealed that moscatin exhibited significant effects on morphological transition and biofilm formation in C. albicans SC5314. It also lowered the pathogenicity of C. albicans SC5314 in a concentration-dependent way in both A549 cells and mice fungal infection models, but had no cytotoxicity to A549 cells. In addition, moscatin attenuated the virulence of clinical fluconazole-resistant C. albicans and exhibited synergistic activity with fluconazole. It could also restore the composition and richness of the intestinal microbiota in mice infected by C. albicans. These findings indicate that these moscatin has great potential to be developed as a new therapeutic drug against C. albicans infection.
•Moscatin is a promising agent for the treatment of C. albicans infection.•Moscatin interferes with the cAMP-PKA and MAPK pathways in C. albicans.•Moscatin exhibited excellent activity against C. albicans SC5314 infection in vitro and in vivo.•Moscatin can enhance the effectiveness of antibiotics.•Moscatin can significantly improve the intestinal microflora in mice infection model.</description><subject>A549 Cells</subject><subject>Animals</subject><subject>Antifungal Agents - pharmacology</subject><subject>biofilm</subject><subject>Biofilm formation</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - pathogenicity</subject><subject>Candidiasis - drug therapy</subject><subject>Candidiasis - microbiology</subject><subject>cytotoxicity</subject><subject>Dendrobium - chemistry</subject><subject>Dendrobium - microbiology</subject><subject>Dendrobium nobile</subject><subject>Disease Models, Animal</subject><subject>drug resistance</subject><subject>Drug Resistance, Fungal</subject><subject>Drug Synergism</subject><subject>fluconazole</subject><subject>Fluconazole - pharmacology</subject><subject>fungi</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Humans</subject><subject>hyphae</subject><subject>Hyphae - drug effects</subject><subject>Hyphae - growth & development</subject><subject>Hyphae formation</subject><subject>intestinal microorganisms</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbial Sensitivity Tests</subject><subject>Moscatin</subject><subject>pathogenesis</subject><subject>Plant Extracts - pharmacology</subject><subject>synergism</subject><subject>therapeutics</subject><subject>Virulence</subject><subject>Virulence - drug effects</subject><issn>0882-4010</issn><issn>1096-1208</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAUhYMoOj5-gpKlm45JmqbJSmR8DQgi6DqkyS1maJMxaQX_vR1mdKurA5fvnAsfQueUzCmh4mo1771dm-F9zgjj060mUu2hGSVKFJQRuY9mREpWcELJETrOeUUIUbxUh-ioVLyuScln6GUZ3n3jBx8Dji1emOC8M9h0jbcmZPzp09hBsICbL9zHbM3gA25T7PEtBJdi48cehyk6wJ0PrjtFB63pMpzt8gS93d-9Lh6Lp-eH5eLmqbCsFkNBKylbZWtmmaIGuJAUSNO20lkumGM1o7yuRCVNK6gUQgKw0taVEmAV5015gi63u-sUP0bIg-59ttB1JkAcsy5pxek0wOg_UMZEKZViE1ptUZtizglavU6-N-lLU6I34vVK78TrjXi9FT_1LnYvxqYH99v6MT0B11sAJiefHpLO1m_EOp_ADtpF_8eLb0GGla8</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wang, Bing</creator><creator>Tan, Huihui</creator><creator>Sun, Xiuyun</creator><creator>Lin, Zizi</creator><creator>Chen, Xiayu</creator><creator>Han, Hongguang</creator><creator>Wang, Mingfang</creator><creator>Wang, Zijie</creator><creator>Chen, Xiangxiu</creator><creator>Deng, Yinyue</creator><creator>Song, Shihao</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-0258-4065</orcidid></search><sort><creationdate>202412</creationdate><title>Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl</title><author>Wang, Bing ; Tan, Huihui ; Sun, Xiuyun ; Lin, Zizi ; Chen, Xiayu ; Han, Hongguang ; Wang, Mingfang ; Wang, Zijie ; Chen, Xiangxiu ; Deng, Yinyue ; Song, Shihao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-1588f9c72c291ae4681e0bff8dc462d2721475658af618668ee23c7596ec944b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>A549 Cells</topic><topic>Animals</topic><topic>Antifungal Agents - pharmacology</topic><topic>biofilm</topic><topic>Biofilm formation</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - pathogenicity</topic><topic>Candidiasis - drug therapy</topic><topic>Candidiasis - microbiology</topic><topic>cytotoxicity</topic><topic>Dendrobium - chemistry</topic><topic>Dendrobium - microbiology</topic><topic>Dendrobium nobile</topic><topic>Disease Models, Animal</topic><topic>drug resistance</topic><topic>Drug Resistance, Fungal</topic><topic>Drug Synergism</topic><topic>fluconazole</topic><topic>Fluconazole - pharmacology</topic><topic>fungi</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Humans</topic><topic>hyphae</topic><topic>Hyphae - drug effects</topic><topic>Hyphae - growth & development</topic><topic>Hyphae formation</topic><topic>intestinal microorganisms</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbial Sensitivity Tests</topic><topic>Moscatin</topic><topic>pathogenesis</topic><topic>Plant Extracts - pharmacology</topic><topic>synergism</topic><topic>therapeutics</topic><topic>Virulence</topic><topic>Virulence - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Tan, Huihui</creatorcontrib><creatorcontrib>Sun, Xiuyun</creatorcontrib><creatorcontrib>Lin, Zizi</creatorcontrib><creatorcontrib>Chen, Xiayu</creatorcontrib><creatorcontrib>Han, Hongguang</creatorcontrib><creatorcontrib>Wang, Mingfang</creatorcontrib><creatorcontrib>Wang, Zijie</creatorcontrib><creatorcontrib>Chen, Xiangxiu</creatorcontrib><creatorcontrib>Deng, Yinyue</creatorcontrib><creatorcontrib>Song, Shihao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bing</au><au>Tan, Huihui</au><au>Sun, Xiuyun</au><au>Lin, Zizi</au><au>Chen, Xiayu</au><au>Han, Hongguang</au><au>Wang, Mingfang</au><au>Wang, Zijie</au><au>Chen, Xiangxiu</au><au>Deng, Yinyue</au><au>Song, Shihao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2024-12</date><risdate>2024</risdate><volume>197</volume><spage>107089</spage><pages>107089-</pages><artnum>107089</artnum><issn>0882-4010</issn><issn>1096-1208</issn><eissn>1096-1208</eissn><abstract>Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases caused by C. albicans. We screened moscatin, and assessed the inhibitory effectiveness against C. albicans SC5314 on hyphae production and biofilm formation. It was revealed that moscatin exhibited significant effects on morphological transition and biofilm formation in C. albicans SC5314. It also lowered the pathogenicity of C. albicans SC5314 in a concentration-dependent way in both A549 cells and mice fungal infection models, but had no cytotoxicity to A549 cells. In addition, moscatin attenuated the virulence of clinical fluconazole-resistant C. albicans and exhibited synergistic activity with fluconazole. It could also restore the composition and richness of the intestinal microbiota in mice infected by C. albicans. These findings indicate that these moscatin has great potential to be developed as a new therapeutic drug against C. albicans infection.
•Moscatin is a promising agent for the treatment of C. albicans infection.•Moscatin interferes with the cAMP-PKA and MAPK pathways in C. albicans.•Moscatin exhibited excellent activity against C. albicans SC5314 infection in vitro and in vivo.•Moscatin can enhance the effectiveness of antibiotics.•Moscatin can significantly improve the intestinal microflora in mice infection model.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39477034</pmid><doi>10.1016/j.micpath.2024.107089</doi><orcidid>https://orcid.org/0000-0003-0258-4065</orcidid></addata></record> |
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| subjects | A549 Cells Animals Antifungal Agents - pharmacology biofilm Biofilm formation Biofilms - drug effects Biofilms - growth & development Candida albicans Candida albicans - drug effects Candida albicans - pathogenicity Candidiasis - drug therapy Candidiasis - microbiology cytotoxicity Dendrobium - chemistry Dendrobium - microbiology Dendrobium nobile Disease Models, Animal drug resistance Drug Resistance, Fungal Drug Synergism fluconazole Fluconazole - pharmacology fungi Gastrointestinal Microbiome - drug effects Humans hyphae Hyphae - drug effects Hyphae - growth & development Hyphae formation intestinal microorganisms Mice Mice, Inbred BALB C Microbial Sensitivity Tests Moscatin pathogenesis Plant Extracts - pharmacology synergism therapeutics Virulence Virulence - drug effects |
| title | Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl |
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