Development of recombinant secondary antibody mimics (rSAMs) for immunoassays through genetic fusion of monomeric alkaline phosphatase with antibody binders

In conventional immunoassays, a secondary antibody is used to amplify the signal generated by the binding of the primary antibody to the target analyte. Due to concerns regarding animal use and cost-inefficiency of secondary antibody productions, there is a significant demand for the development of...

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Veröffentlicht in:	International journal of biological macromolecules 2023-11, Vol.251, p.126299, Article 126299
Hauptverfasser:	Park, Jiyeon, Bae, Yoonji, Eom, Soomin, Choi, Yuha, Lee, Giwook, Kang, Sebyung
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaline phosphatase Alkaline Phosphatase - chemistry Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals antibodies Antibodies - chemistry Antibodies - genetics Antibodies - immunology chemical species Enzyme-Linked Immunosorbent Assay - methods Immunoassay - methods Immunoglobulin G - genetics Immunoglobulin G - immunology Mice Rabbits Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Single-Domain Antibodies - chemistry Single-Domain Antibodies - genetics Single-Domain Antibodies - immunology streptavidin
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