Nuclear translocation of the membrane oxoeicosanoid/androgen receptor, OXER1: Possible mechanisms involved

OXER1, the receptor for the arachidonic acid metabolite 5-οxo-eicosatetraenoic acid (5-oxo-ETE), has been reported to also bind and mediate the membrane-initiated actions of androgens. Indeed, androgens antagonize the 5-oxo-ETE effects through OXER1, affecting a number of signaling pathways and inhi...

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Veröffentlicht in:	Molecular and cellular endocrinology 2024-12, Vol.594, p.112357, Article 112357
Hauptverfasser:	Malamos, Panagiotis, Kalyvianaki, Konstantina, Panagiotopoulos, Athanasios A., Vogiatzoglou, Amalia P., Tsikalaki, Athanasia Artemis, Katifori, Anastasia, Polioudaki, Hara, Darivianaki, Maria N., Theodoropoulos, Panayiotis A., Panagiotidis, Christos A., Notas, George, Castanas, Elias, Kampa, Marilena
Format:	Artikel
Sprache:	eng
Schlagworte:	5-oxo-ETE Active Transport, Cell Nucleus - drug effects agonists androgen receptors Animals arachidonic acid Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism cell proliferation CHO Cells computer simulation Cricetulus endocrinology fluorescent antibody technique GPCR Humans importins ligands Lipoylation Male mechanism of action Membrane androgen receptor metabolites neoplasm cells Nuclear localization OXER1 palmitoylation plasma membrane prostatic neoplasms Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Receptors, Eicosanoid - metabolism Testosterone therapeutics Western blotting
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