IGFBP5 in osteosarcoma tumorigenesis: Gene expression profile among metastatic and non-metastatic patients

•Osteosarcoma is a malignant bone tumor that affects children and adolescents.•Metastasis at diagnosis significantly decreases the chances of survival.•IGFBP5 expression varies among tumors from metastatic and non-metastatic patients.•IGFBP5 gene may be related to MAPK pathway modulation.•Investigat...

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Veröffentlicht in:	Gene 2025-01, Vol.934, p.149026, Article 149026
Hauptverfasser:	Guimarães, G.M., Tesser-Gamba, F., Petrilli, A.S., Alves, M.T.S., Garcia-Filho, R.J., Oliveira, R., Toledo, S.R.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	carcinogenesis drug therapy Gene expression genes IGFBP5 gene lungs MAPKs Pathway metabolism metastasis osteoblasts Osteosarcoma patients Pulmonary metastasis quantitative polymerase chain reaction
Online-Zugang:	Volltext
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