Apple Polyphenol Extracts Attenuated Depressive-Like Behaviors of High-Sucrose Diet Feeding Mice by Farnesoid X Receptor-Mediated Modulation of Bile Acid Circulation within the Liver–Gut–Brain Axis

Although the association between high-sugar diets and depression has been verified, few studies have explored the antidepressant mechanisms of apple polyphenol extracts (APE). Therefore, fifty-four C57BL/6 male mice aged 5 weeks were randomly assigned into five groups: the control group with the sta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of agricultural and food chemistry 2024-11, Vol.72 (45), p.25118-25134
Hauptverfasser:	Xie, Yisha, Shang, Siyuan, Luan, Wenxue, Ma, Jieyu, Yang, Hao, Qian, Qingfan, Wu, Zhengli, Li, Xinli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology apples Behavior, Animal - drug effects bile Bile Acids and Salts - metabolism Bioactive Constituents, Metabolites, and Functions blood serum brain Brain - drug effects Brain - metabolism Brain-Gut Axis - drug effects Chlorogenic Acid colon corticosterone Corticosterone - blood Corticosterone - metabolism corticotropin Depression - drug therapy Depression - metabolism Dietary Sucrose - adverse effects dietary supplements Firmicutes Flavonoids food chemistry Gastrointestinal Microbiome - drug effects glycocholic acid high carbohydrate diet histopathology Humans liver Liver - drug effects Liver - metabolism Male males Malus - chemistry Mice Mice, Inbred C57BL microorganisms occludins Plant Extracts - administration & dosage polyphenols Polyphenols - administration & dosage Polyphenols - pharmacology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Tannins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!