Mechanistic Investigations of Chiral Lithium Binaphtholate Catalysis for Asymmetric Aldol–Tishchenko Reaction of α‑Fluoroarylketones

In this study, we analyzed the asymmetric aldol-Tishchenko reaction of α-fluoroarylketones with aldehydes in the presence of chiral lithium binaphtholate, which was readily prepared from a chiral BINOL derivative and lithium tert-butoxide. This tandem reaction afforded enantiomerically enriched 2-fl...

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Veröffentlicht in:	Journal of organic chemistry 2024-12, Vol.89 (23), p.17101-17114
Hauptverfasser:	Kotani, Shunsuke, Asano, Toshifumi, Arae, Sachie, Sugiura, Masaharu, Nakajima, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	catalytic activity enantioselectivity isotopes lithium organic chemistry
Online-Zugang:	Volltext
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