Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation

Jianpi Huayu Decoction (JHD) is an herbal prescription in traditional Chinese medicine based on Sijunzi Decoction to treat patients with colorectal cancer (CRC). Its effects on the inhibition of CRC cell proliferation and tumor growth are promising; however, its multicomponent nature makes a complet...

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Veröffentlicht in:	Journal of ethnopharmacology 2024-01, Vol.319 (Pt 3), p.117347-117347, Article 117347
Hauptverfasser:	Wang, Shiting, Xing, Ying, Wang, Ruiping, Jin, Zhichao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioinformatics biomarkers cell proliferation cell senescence Cellular Senescence colorectal neoplasms Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics gene expression Humans Molecular Docking Simulation Network Pharmacology Oriental traditional medicine pharmacology Tumor Suppressor Protein p53 - genetics xenotransplantation
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