Comparative analysis of mutational patterns in triple negative breast cancer before and after neoadjuvant chemotherapy in patients with residual disease

•TNBC remains a heterogeneous and challenging subset of breast cancer.•The mutational landscape in TNBC patients with residual disease remains stable pre- and post-NAC, with no recurrent variants evident.•Post-NAC samples showed a significant increase in AR gene variants, suggesting potential progno...

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Veröffentlicht in:	Gene 2024-02, Vol.895, p.147980-147980, Article 147980
Hauptverfasser:	Singh, Ashish, Georgy, Josh Thomas, Dhananjayan, Sakthi, Sigamani, Elanthenral, John, Ajoy Oommen, Joel, Anjana, Chandramohan, Jagan, Abarna, Rajadurai, Rebekah, Grace, Backianathan, Selvamani, Abraham, Deepak Thomas, Paul, Mazhuvanchary Jacob, Chacko, Raju Titus, Manipadam, Marie Therese, Pai, Rekha
Format:	Artikel
Sprache:	eng
Schlagworte:	breast neoplasms death drug therapy genes mutation Neo-adjuvant chemotherapy Next generation sequencing pathogenesis platinum Pre- and post-NAC samples prediction Recurrent mutations relapse risk sample size Somatic mutations Triple-negative breast cancer
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