A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro

The blood-brain barrier (BBB) maintains brain homeostasis but also prevents most drugs from entering the brain. No paracellular diffusion of solutes is allowed because of tight junctions that are made impermeable by the expression of claudin5 (CLDN5) by brain endothelial cells. The possibility of re...

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Veröffentlicht in:	Science advances 2025-01, Vol.11 (2), p.eadq2616
Hauptverfasser:	Trevisani, Martina, Berselli, Alessandro, Alberini, Giulio, Centonze, Eleonora, Vercellino, Silvia, Cartocci, Veronica, Millo, Enrico, Ciobanu, Dinu Zinovie, Braccia, Clarissa, Armirotti, Andrea, Pisani, Francesco, Zara, Federico, Castagnola, Valentina, Maragliano, Luca, Benfenati, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Claudin-5 - metabolism Endothelial Cells - metabolism Enterotoxins - chemistry Enterotoxins - metabolism Humans Peptides - chemistry Peptides - metabolism Peptides - pharmacology Permeability Protein Binding
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