The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite

Polycystic ovary syndrome (PCOS) affects 6%–10% of women of reproductive age and is known to be associated with disruptions in the gut bacteria. However, the role of the gut mycobiota in PCOS pathology remains unclear. Using culture-dependent and internal transcribed spacer 2 (ITS2)-sequencing metho...

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Veröffentlicht in:	Cell host & microbe 2025-01, Vol.33 (1), p.119-136.e11
Hauptverfasser:	Wu, Jiayu, Wang, Kai, Qi, Xinyu, Zhou, Shuang, Zhao, Shuyun, Lu, Meisong, Nie, Qixing, Li, Meng, Han, Mengwei, Luo, Xi, Yun, Chuyu, Wang, Pengcheng, Li, Rong, Zhong, Chao, Yu, Xiaofei, Yin, Wen-bing, Jiang, Changtao, Qiao, Jie, Pang, Yanli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspergillus - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism China Disease Models, Animal Female Gastrointestinal Microbiome gut microbiota gut mycobiota Humans Interleukins - metabolism Intestines - microbiology Intestines - pathology Lymphocytes - immunology Lymphocytes - metabolism Mice Mice, Inbred C57BL PCOS Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - microbiology Receptors, Aryl Hydrocarbon - metabolism Secondary Metabolism secondary metabolite Signal Transduction
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