Refining fine-mapping: Effect sizes and regional heritability

Recent statistical approaches have shown that the set of all available genetic variants explains considerably more phenotypic variance of complex traits and diseases than the individual variants that are robustly associated with these phenotypes. However, rapidly increasing sample sizes constantly i...

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Veröffentlicht in:	PLoS genetics 2025-01, Vol.21 (1), p.e1011480
Hauptverfasser:	Benner, Christian, Mahajan, Anubha, Pirinen, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Chromosome Mapping - methods Genetic Variation Genome-Wide Association Study - methods Humans Models, Genetic Multifactorial Inheritance - genetics Phenotype Physical Sciences Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci Research and Analysis Methods Software
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