Formation of I2+III2 supercomplex rescues respiratory chain defects

Mitochondrial electron transport chain (ETC) complexes partition between free complexes and quaternary assemblies known as supercomplexes (SCs). However, the physiological requirement for SCs and the mechanisms regulating their formation remain controversial. Here, we show that genetic perturbations...

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Veröffentlicht in:	Cell metabolism 2025-01
Hauptverfasser:	Liang, Chao, Padavannil, Abhilash, Zhang, Shan, Beh, Sheryl, Robinson, David R.L., Meisterknecht, Jana, Cabrera-Orefice, Alfredo, Koves, Timothy R., Watanabe, Chika, Watanabe, Miyuki, Illescas, María, Lim, Radiance, Johnson, Jordan M., Ren, Shuxun, Wu, Ya-Jun, Kappei, Dennis, Ghelli, Anna Maria, Funai, Katsuhiko, Osaka, Hitoshi, Muoio, Deborah, Ugalde, Cristina, Wittig, Ilka, Stroud, David A., Letts, James A., Ho, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	complex I complex III complex III ROS cryo-EM structure electron transport chain ischemia reperfusion injury mitohormesis respirasome reverse electron transport supercomplex
Online-Zugang:	Volltext
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