Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals

Microbiota composition regulates colitis severity, yet the innate immune mechanisms that control commensal communities and prevent disease remain unclear. We show that the innate immune receptor, Clec12a, impacts colitis severity by regulating microbiota composition. Transplantation of microbiota fr...

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Veröffentlicht in:	Cell host & microbe 2025-01, Vol.33 (1), p.89-103.e7
Hauptverfasser:	Chiaro, Tyson R., Greenewood, Morgan, Bauer, Kaylyn M., Ost, Kyla S., Stephen-Victor, Emmanuel, Murphy, Michaela, Weis, Allison M., Nelson, Morgan C., Hill, Jennifer H., Bell, Rickesha, Voth, Warren, Jackson, Taylor, Klag, Kendra A., O’Connell, Ryan M., Zac Stephens, W., Round, June L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C-Type Lectin Clec12a Colitis - immunology Colitis - microbiology Cytokines - metabolism Disease Models, Animal F. rodentium Gastrointestinal Microbiome immune regulation Immunity, Innate Inflammation intestine Lectins, C-Type - genetics Lectins, C-Type - metabolism macrophage Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred C57BL Mice, Knockout microbiota Monocytes - immunology Phagocytosis Receptors, Mitogen - genetics Receptors, Mitogen - metabolism Symbiosis
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