Exploring caffeine as a disruptor of membrane integrity and genomic stability in Staphylococcus aureus: functional and in silico analysis

To explore the mechanistic underpinnings of caffeine as a potent antibacterial against Staphylococcus aureus ATCC 25923 via in vitro functional assays, whole-genome sequencing, and in silico docking studies. In vitro studies established that caffeine’s minimum inhibitory concentration (MIC) against...

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Veröffentlicht in:	Archives of microbiology 2025-02, Vol.207 (2), p.28, Article 28
Hauptverfasser:	Beulah, K. C., Prasanna, Akshatha, Karunakar, Prashantha, Rao, Archana S., More, Sunil S., Nair, Ajay
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial agents Assaying Biochemistry Biomedical and Life Sciences Biotechnology Caffeine Caffeine - metabolism Caffeine - pharmacology Cell Biology Cell Membrane - drug effects Cell Membrane - metabolism Cell membranes Cell walls Computer Simulation DNA repair Ecology Efflux Gene mapping Gene sequencing Genome, Bacterial Genomes Genomic analysis Genomic Instability Genomics Integrity Life Sciences Membranes Microbial Ecology Microbial Sensitivity Tests Microbiology Minimum inhibitory concentration Molecular Docking Simulation Nucleotides Original Paper Polymorphism, Single Nucleotide Potassium Scanning electron microscopy Single-nucleotide polymorphism Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Virulence Whole Genome Sequencing
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