New insights on the regulators and inhibitors of RhoA-ROCK signalling in Parkinson’s disease

A multifaceted and widely prevalent neurodegenerative disease, Parkinson's disease (PD) is typified by the loss of dopaminergic neurons in the midbrain. The discovery of novel treatment(s) that can reverse or halt the course of the disease progression along with identifying the most reliable bi...

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Veröffentlicht in:	Metabolic brain disease 2025-01, Vol.40 (1), p.90, Article 90
Hauptverfasser:	Ravichandran, Nandita, Iyer, Mahalaxmi, Uvarajan, Deenathayalan, Kirola, Laxmi, Kumra, Sindduja Muthu, Babu, Harysh winster Suresh, HariKrishnaReddy, Dibbanti, Vellingiri, Balachandar, Narayanasamy, Arul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal transport Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Dopamine receptors Effector cells Glial cells Humans Illnesses Mesencephalon Metabolic Diseases Movement disorders Nervous system Neurodegeneration Neurodegenerative diseases Neurology Neuronal-glial interactions Neurons Neurosciences Oncology Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Pathophysiology Protein transport Proteins Review rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - metabolism RhoA protein Rocks Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signalling systems Synuclein Therapeutic applications
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