Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort
Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD...
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| creator | Roth, Eliane Bruni, Cosimo Petelytska, Liubov Becker, Mike Oliver Dobrota, Rucsandra Jordan, Suzana Mihai, Carina Muraru, Sinziana Carreira, Patricia E De Vries-Bouwstra, Jeska Braun-Moscovici, Yolanda Liakouli, Vasiliki Moroncini, Gianluca Bergmann, Christina Mouthon, Luc Denton, Christopher P De Santis, Maria Cauli, Alberto Adler, Sabine Bernardino, Vera Truchetet, Marie-Elise Vonk, Madelon Del Galdo, Francesco Hoffmann-Vold, Anna-Maria Distler, Oliver Elhai, Muriel |
| description | Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.
SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥ 15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression.
5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p |
| doi_str_mv | 10.1093/rheumatology/keaf016 |
| format | Article |
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SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥ 15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression.
5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p < 0.001) and more severe lung involvement with lower FVC (85.8±22.1 vs 90.2±20.1, p < 0.001), lower DLCO (60.8±19.7 vs 65.3±20.6, p < 0.001) and worse performance at the 6-minute walking test. Female sex (HR: 1.39 [1.07-1.80], p = 0.012) and older age (HR: 1.02 [1.01-1.03], p < 0.001) independently predicted ILD progression in SSc-ILD patients with GERD.
SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered as risk factor for ILD progression.</description><identifier>ISSN: 1462-0324</identifier><identifier>ISSN: 1462-0332</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keaf016</identifier><identifier>PMID: 39775478</identifier><language>eng</language><publisher>England</publisher><ispartof>Rheumatology (Oxford, England), 2025-01</ispartof><rights>The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Rheumatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39775478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, Eliane</creatorcontrib><creatorcontrib>Bruni, Cosimo</creatorcontrib><creatorcontrib>Petelytska, Liubov</creatorcontrib><creatorcontrib>Becker, Mike Oliver</creatorcontrib><creatorcontrib>Dobrota, Rucsandra</creatorcontrib><creatorcontrib>Jordan, Suzana</creatorcontrib><creatorcontrib>Mihai, Carina</creatorcontrib><creatorcontrib>Muraru, Sinziana</creatorcontrib><creatorcontrib>Carreira, Patricia E</creatorcontrib><creatorcontrib>De Vries-Bouwstra, Jeska</creatorcontrib><creatorcontrib>Braun-Moscovici, Yolanda</creatorcontrib><creatorcontrib>Liakouli, Vasiliki</creatorcontrib><creatorcontrib>Moroncini, Gianluca</creatorcontrib><creatorcontrib>Bergmann, Christina</creatorcontrib><creatorcontrib>Mouthon, Luc</creatorcontrib><creatorcontrib>Denton, Christopher P</creatorcontrib><creatorcontrib>De Santis, Maria</creatorcontrib><creatorcontrib>Cauli, Alberto</creatorcontrib><creatorcontrib>Adler, Sabine</creatorcontrib><creatorcontrib>Bernardino, Vera</creatorcontrib><creatorcontrib>Truchetet, Marie-Elise</creatorcontrib><creatorcontrib>Vonk, Madelon</creatorcontrib><creatorcontrib>Del Galdo, Francesco</creatorcontrib><creatorcontrib>Hoffmann-Vold, Anna-Maria</creatorcontrib><creatorcontrib>Distler, Oliver</creatorcontrib><creatorcontrib>Elhai, Muriel</creatorcontrib><creatorcontrib>EUSTAR collaborators</creatorcontrib><title>Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.
SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥ 15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression.
5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p < 0.001) and more severe lung involvement with lower FVC (85.8±22.1 vs 90.2±20.1, p < 0.001), lower DLCO (60.8±19.7 vs 65.3±20.6, p < 0.001) and worse performance at the 6-minute walking test. Female sex (HR: 1.39 [1.07-1.80], p = 0.012) and older age (HR: 1.02 [1.01-1.03], p < 0.001) independently predicted ILD progression in SSc-ILD patients with GERD.
SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered as risk factor for ILD progression.</description><issn>1462-0324</issn><issn>1462-0332</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNpNUclOwzAQtRCIsv0BQj5yKXiJ4-RYVWWRkJBYzpHrTBpDUhePA_QD-G-MKMtpRjPvvRm9R8gxZ2eclfI8tDD0JvrOL9bnz2AaxvMtssezXIyZlGL7txfZiOwjPjHGFJfFLhnJUmuV6WKPfFwajMED-lVrFmA6GqDphndaOwSDQB1Sg-itMxFq-uZiSw3tfQCK8AqpuGWEgNFFl8jdsFz8UZcU1xihd5ai7SB4TGppGlugs8f7h8kdtb71IR6SncZ0CEebekAeL2YP06vxze3l9XRyM7ac8WKsuRDMioJx0VidlWoOUHPIlSxFrYU23OaMNZCXds7TSmmVy0xZDVqJstDygJx-666CfxkAY9U7tNB1Zgl-wEpyJQudZ4wnaPYNteltTKZUq-B6E9YVZ9VXANX_AKpNAIl2srkwzHuof0k_jstP1tSIzw</recordid><startdate>20250108</startdate><enddate>20250108</enddate><creator>Roth, Eliane</creator><creator>Bruni, Cosimo</creator><creator>Petelytska, Liubov</creator><creator>Becker, Mike Oliver</creator><creator>Dobrota, Rucsandra</creator><creator>Jordan, Suzana</creator><creator>Mihai, Carina</creator><creator>Muraru, Sinziana</creator><creator>Carreira, Patricia E</creator><creator>De Vries-Bouwstra, Jeska</creator><creator>Braun-Moscovici, Yolanda</creator><creator>Liakouli, Vasiliki</creator><creator>Moroncini, Gianluca</creator><creator>Bergmann, Christina</creator><creator>Mouthon, Luc</creator><creator>Denton, Christopher P</creator><creator>De Santis, Maria</creator><creator>Cauli, Alberto</creator><creator>Adler, Sabine</creator><creator>Bernardino, Vera</creator><creator>Truchetet, Marie-Elise</creator><creator>Vonk, Madelon</creator><creator>Del Galdo, Francesco</creator><creator>Hoffmann-Vold, Anna-Maria</creator><creator>Distler, Oliver</creator><creator>Elhai, Muriel</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250108</creationdate><title>Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort</title><author>Roth, Eliane ; 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We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.
SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥ 15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression.
5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p < 0.001) and more severe lung involvement with lower FVC (85.8±22.1 vs 90.2±20.1, p < 0.001), lower DLCO (60.8±19.7 vs 65.3±20.6, p < 0.001) and worse performance at the 6-minute walking test. Female sex (HR: 1.39 [1.07-1.80], p = 0.012) and older age (HR: 1.02 [1.01-1.03], p < 0.001) independently predicted ILD progression in SSc-ILD patients with GERD.
SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered as risk factor for ILD progression.</abstract><cop>England</cop><pmid>39775478</pmid><doi>10.1093/rheumatology/keaf016</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort |
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