The Influence of Diet and Obesity in Lynch Syndrome: What Do We Know So Far
Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and di...
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| Veröffentlicht in: | Nutrients 2024-12, Vol.16 (24), p.4352 |
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| creator | Rodrigues, Cláudio Irving, Susana Couto Alves, Paula Dinis-Ribeiro, Mário Brandão, Catarina Correia, Marta |
| description | Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS's clinical evolution. There is some evidence suggesting that individuals living with LS should follow general guidelines for diet and alcohol restriction/moderation, so as to achieve and maintain a favorable weight status and overall health and quality of life. However, more research is needed, preferentially from clinical studies of a prospective nature with robust designs, to better inform diet and behavioral patterns targeting cancer prevention in LS. |
| doi_str_mv | 10.3390/nu16244352 |
| format | Article |
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This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS's clinical evolution. There is some evidence suggesting that individuals living with LS should follow general guidelines for diet and alcohol restriction/moderation, so as to achieve and maintain a favorable weight status and overall health and quality of life. 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| subjects | Age Alcohol use Cancer research Cell growth Cohort analysis Colonoscopy Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Diet Dietary fiber Dietary supplements Genetic disorders Humans Meat Medical research Mutation Nutrition research Obesity Obesity - genetics Quality of Life Risk Factors Smoking Tumors Vitamin B Vitamin C |
| title | The Influence of Diet and Obesity in Lynch Syndrome: What Do We Know So Far |
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