Synthesis and Activity of T‑Cell Tumor-Directing MegaMolecules

This paper describes the synthesis, characterization, and functional activity of 26 MegaMolecule-based bispecific antibody mimics for T-cell redirection toward HER2+ cancer cells. The work reports functional bispecific MegaMolecules that bind both receptor targets, and recruit and activate T-cells r...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-10, Vol.146 (39), p.26801-26807
Hauptverfasser:	Sridhar, Sraeyes, Modica, Justin A., Sykora, Daniel J., Berns, Eric J., Mrksich, Milan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies Antibodies, Bispecific - chemistry Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - pathology CD3 Complex - immunology Cell Line, Tumor Female Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Mice Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism T-lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology xenotransplantation
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