Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing
Diabetic wounds have been a serious concern for human health owing to their long chronic inflammation and reduced vascularization. Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the...
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| Veröffentlicht in: | International journal of biological macromolecules 2023-01, Vol.226, p.1490-1499 |
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| container_title | International journal of biological macromolecules |
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| creator | Ding, Xiaofeng Li, Shiyan Tian, Meng Yang, Ping Ding, Youjun Wang, Yiwei Duan, Guomei Zhang, Daihui Chen, Bin Tan, Qian |
| description | Diabetic wounds have been a serious concern for human health owing to their long chronic inflammation and reduced vascularization. Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the treatment of diabetic wounds. The size and morphology of NEs are analyzed by transmission electron microscope (TEM) and Zeta potential, respectively. Furthermore, the rheological behavior and morphology of synthesized hydrogels are also determined. It is found that PTE-NEs gel has a homogeneous and porous structure with good elastic properties. In addition, in vitro experiments show that the cell viability of PTE-NEs gel is >85 % without cytotoxicity. In vivo experiments of diabetic rats demonstrate that the PTE-NEs gel can not only significantly accelerate diabetic wound healing, collagen deposition, M2 macrophage polarization, and angiogenesis, but also inhibit inflammation. In conclusion, PTE plays a significant role in wound healing and exhibits anti-inflammatory effects, demonstrating its great potential in treating diabetic wounds. |
| doi_str_mv | 10.1016/j.ijbiomac.2022.11.261 |
| format | Article |
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Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the treatment of diabetic wounds. The size and morphology of NEs are analyzed by transmission electron microscope (TEM) and Zeta potential, respectively. Furthermore, the rheological behavior and morphology of synthesized hydrogels are also determined. It is found that PTE-NEs gel has a homogeneous and porous structure with good elastic properties. In addition, in vitro experiments show that the cell viability of PTE-NEs gel is >85 % without cytotoxicity. In vivo experiments of diabetic rats demonstrate that the PTE-NEs gel can not only significantly accelerate diabetic wound healing, collagen deposition, M2 macrophage polarization, and angiogenesis, but also inhibit inflammation. In conclusion, PTE plays a significant role in wound healing and exhibits anti-inflammatory effects, demonstrating its great potential in treating diabetic wounds.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2022.11.261</identifier><identifier>PMID: 36442559</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>angiogenesis ; Animals ; Bandages ; cell viability ; collagen ; cytotoxicity ; Diabetes Mellitus, Experimental - drug therapy ; Diabetic wound ; human health ; Humans ; Hyaluronic acid ; Hyaluronic Acid - chemistry ; Hydrogels ; Hydrogels - chemistry ; Inflammation ; macrophages ; Nanoemulsions ; Poria ; Poria cocos ; Rats ; rheological properties ; transmission electron microscopes ; Triterpenes - pharmacology ; triterpenoids ; Wolfiporia ; zeta potential</subject><ispartof>International journal of biological macromolecules, 2023-01, Vol.226, p.1490-1499</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-ffb799b568e322b99641103e4ab4ef11ac4deebac899edf5f2380d61e46baaeb3</citedby><cites>FETCH-LOGICAL-c401t-ffb799b568e322b99641103e4ab4ef11ac4deebac899edf5f2380d61e46baaeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813022028203$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36442559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Xiaofeng</creatorcontrib><creatorcontrib>Li, Shiyan</creatorcontrib><creatorcontrib>Tian, Meng</creatorcontrib><creatorcontrib>Yang, Ping</creatorcontrib><creatorcontrib>Ding, Youjun</creatorcontrib><creatorcontrib>Wang, Yiwei</creatorcontrib><creatorcontrib>Duan, Guomei</creatorcontrib><creatorcontrib>Zhang, Daihui</creatorcontrib><creatorcontrib>Chen, Bin</creatorcontrib><creatorcontrib>Tan, Qian</creatorcontrib><title>Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Diabetic wounds have been a serious concern for human health owing to their long chronic inflammation and reduced vascularization. Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the treatment of diabetic wounds. The size and morphology of NEs are analyzed by transmission electron microscope (TEM) and Zeta potential, respectively. Furthermore, the rheological behavior and morphology of synthesized hydrogels are also determined. It is found that PTE-NEs gel has a homogeneous and porous structure with good elastic properties. In addition, in vitro experiments show that the cell viability of PTE-NEs gel is >85 % without cytotoxicity. In vivo experiments of diabetic rats demonstrate that the PTE-NEs gel can not only significantly accelerate diabetic wound healing, collagen deposition, M2 macrophage polarization, and angiogenesis, but also inhibit inflammation. In conclusion, PTE plays a significant role in wound healing and exhibits anti-inflammatory effects, demonstrating its great potential in treating diabetic wounds.</description><subject>angiogenesis</subject><subject>Animals</subject><subject>Bandages</subject><subject>cell viability</subject><subject>collagen</subject><subject>cytotoxicity</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetic wound</subject><subject>human health</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Inflammation</subject><subject>macrophages</subject><subject>Nanoemulsions</subject><subject>Poria</subject><subject>Poria cocos</subject><subject>Rats</subject><subject>rheological properties</subject><subject>transmission electron microscopes</subject><subject>Triterpenes - pharmacology</subject><subject>triterpenoids</subject><subject>Wolfiporia</subject><subject>zeta potential</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCK1ResknwOE5usgNVFJAqwQLW1tget75K7GAn_XkGXppc3ZYtq9EcfWdGM4exCxA1COg-HOpwMCFNaGsppKwBatnBC7aDfj9UQojmJdsJUFD10Igz9qaUw6Z2LfSv2VnTKSXbdtixP1dow0h8zjRjxiWkyJPnyGO6o5FHjImmdSxH3WAhx28fcVxzisHyzXrsXU43GzsmdCHe8Puw3PIfKQfkNtlU-JLDQnmmmIIrnB6WjHbhPmV-n9bouMtUyuZ8y155HAu9e6rn7NfV55-XX6vr71--XX66rqwSsFTem_0wmLbrqZHSDEOnAERDCo0iD4BWOSKDth8Gcr71sumF64BUZxDJNOfs_WnunNPvlcqip1AsjSNGSmvRDbRN38Jeyg3tTqjNqZRMXs85TJgfNQh9DEIf9HMQ-hiEBtBbEJvx4mnHaiZy_2zPn9-AjyeAtkvvAmVdbKBoyYVMdtEuhf_t-At1_qGN</recordid><startdate>20230131</startdate><enddate>20230131</enddate><creator>Ding, Xiaofeng</creator><creator>Li, Shiyan</creator><creator>Tian, Meng</creator><creator>Yang, Ping</creator><creator>Ding, Youjun</creator><creator>Wang, Yiwei</creator><creator>Duan, Guomei</creator><creator>Zhang, Daihui</creator><creator>Chen, Bin</creator><creator>Tan, Qian</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20230131</creationdate><title>Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing</title><author>Ding, Xiaofeng ; Li, Shiyan ; Tian, Meng ; Yang, Ping ; Ding, Youjun ; Wang, Yiwei ; Duan, Guomei ; Zhang, Daihui ; Chen, Bin ; Tan, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-ffb799b568e322b99641103e4ab4ef11ac4deebac899edf5f2380d61e46baaeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>angiogenesis</topic><topic>Animals</topic><topic>Bandages</topic><topic>cell viability</topic><topic>collagen</topic><topic>cytotoxicity</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetic wound</topic><topic>human health</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Inflammation</topic><topic>macrophages</topic><topic>Nanoemulsions</topic><topic>Poria</topic><topic>Poria cocos</topic><topic>Rats</topic><topic>rheological properties</topic><topic>transmission electron microscopes</topic><topic>Triterpenes - pharmacology</topic><topic>triterpenoids</topic><topic>Wolfiporia</topic><topic>zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Xiaofeng</creatorcontrib><creatorcontrib>Li, Shiyan</creatorcontrib><creatorcontrib>Tian, Meng</creatorcontrib><creatorcontrib>Yang, Ping</creatorcontrib><creatorcontrib>Ding, Youjun</creatorcontrib><creatorcontrib>Wang, Yiwei</creatorcontrib><creatorcontrib>Duan, Guomei</creatorcontrib><creatorcontrib>Zhang, Daihui</creatorcontrib><creatorcontrib>Chen, Bin</creatorcontrib><creatorcontrib>Tan, Qian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Xiaofeng</au><au>Li, Shiyan</au><au>Tian, Meng</au><au>Yang, Ping</au><au>Ding, Youjun</au><au>Wang, Yiwei</au><au>Duan, Guomei</au><au>Zhang, Daihui</au><au>Chen, Bin</au><au>Tan, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-01-31</date><risdate>2023</risdate><volume>226</volume><spage>1490</spage><epage>1499</epage><pages>1490-1499</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Diabetic wounds have been a serious concern for human health owing to their long chronic inflammation and reduced vascularization. Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the treatment of diabetic wounds. The size and morphology of NEs are analyzed by transmission electron microscope (TEM) and Zeta potential, respectively. Furthermore, the rheological behavior and morphology of synthesized hydrogels are also determined. It is found that PTE-NEs gel has a homogeneous and porous structure with good elastic properties. In addition, in vitro experiments show that the cell viability of PTE-NEs gel is >85 % without cytotoxicity. In vivo experiments of diabetic rats demonstrate that the PTE-NEs gel can not only significantly accelerate diabetic wound healing, collagen deposition, M2 macrophage polarization, and angiogenesis, but also inhibit inflammation. 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| subjects | angiogenesis Animals Bandages cell viability collagen cytotoxicity Diabetes Mellitus, Experimental - drug therapy Diabetic wound human health Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogels Hydrogels - chemistry Inflammation macrophages Nanoemulsions Poria Poria cocos Rats rheological properties transmission electron microscopes Triterpenes - pharmacology triterpenoids Wolfiporia zeta potential |
| title | Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing |
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