SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-CoV-2 traverses the mucus layer, using motile cilia...

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Veröffentlicht in:	Cell 2023-01, Vol.186 (1), p.112-130.e20
Hauptverfasser:	Wu, Chien-Ting, Lidsky, Peter V., Xiao, Yinghong, Cheng, Ran, Lee, Ivan T., Nakayama, Tsuguhisa, Jiang, Sizun, He, Wei, Demeter, Janos, Knight, Miguel G., Turn, Rachel E., Rojas-Hernandez, Laura S., Ye, Chengjin, Chiem, Kevin, Shon, Judy, Martinez-Sobrido, Luis, Bertozzi, Carolyn R., Nolan, Garry P., Nayak, Jayakar V., Milla, Carlos, Andino, Raul, Jackson, Peter K.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway epithelial cells cilia Cilia - physiology Cilia - virology COVID-19 COVID-19 - virology Epithelial Cells - physiology Epithelial Cells - virology epithelium Humans microvilli Microvilli - physiology Microvilli - virology mucins mucus nose organoids phosphotransferases (kinases) progeny protein kinases proteomics respiratory synctital virus Respiratory System - cytology Respiratory System - virology respiratory virus SARS-CoV-2 SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Virus Internalization virus replication viruses
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