A methoxyflavanone from the medicinal herb Perilla frutescens down-modulates Th17 response and ameliorates collagen-induced arthritis

IL-17-producing T-helper 17 (Th17) cells are involved in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA). Here, we show that a methoxyflavanone from the Asian medicinal herb Perilla frutescens (termed Perilla-derived methoxyflavanone, PDMF) suppresses Th17 response and col...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-12, Vol.637, p.294-299
Hauptverfasser:	Maeda, Akira, Hirano, Kouki, Maeda, Shunsuke, Okuizumi, Ayana, Hirakawa, Noriko, Baba, Kenji, Fujimura, Takashi, Kawamoto, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Rheumatoid cell differentiation Collagen-induced arthritis Disease Models, Animal Flavanone Interleukin-17 interleukin-6 medicinal plants Mice pathogenesis Perilla frutescens Plants, Medicinal rheumatoid arthritis secretion T-lymphocytes Th17 cells
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