Chromones from the whole plant of Hypericum elodeoides and their bioactivities
Two chromones and four chromone C-glycosides (1-6), including the new 1, were isolated from the whole plant of Hypericum elodeoides. The structures were characterized by comprehensive analysis of their UV, NMR, ECD and HRESIMS data. The acid hydrolysis of Compounds 1, 2, 4 and 5 demonstrated that th...
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| Veröffentlicht in: | Phytochemistry letters 2023-08, Vol.56, p.1-4 |
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| creator | Mu, Yanbing Cui, Letian Ying, Ping Wen, Huiping Zhan, Dujuan Kong, Lingyi Luo, Jun |
| description | Two chromones and four chromone C-glycosides (1-6), including the new 1, were isolated from the whole plant of Hypericum elodeoides. The structures were characterized by comprehensive analysis of their UV, NMR, ECD and HRESIMS data. The acid hydrolysis of Compounds 1, 2, 4 and 5 demonstrated that the chromone C-glycosides can undergo the Wessely Moser rearrangement. Compound 1 exhibited moderate α-glucosidase inhibitory activity (IC50: 456.26 ± 1.17 µM). Compound 4 could moderately reverse multidrug resistance with an IC50 value of 6.21 ± 0.40 μM (RF: 3.33) in MCF-7/Dox cells.
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•Six chromones (1-6), including the new 1, were isolated from Hypericum elodeoides.•Chromone C-glycosides could undergo the Wessely-Moser rearrangement.•Chromones showed α-glucosidase inhibitory and anti-multidrug resistance activities. |
| doi_str_mv | 10.1016/j.phytol.2023.06.001 |
| format | Article |
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[Display omitted]
•Six chromones (1-6), including the new 1, were isolated from Hypericum elodeoides.•Chromone C-glycosides could undergo the Wessely-Moser rearrangement.•Chromones showed α-glucosidase inhibitory and anti-multidrug resistance activities.</description><identifier>ISSN: 1874-3900</identifier><identifier>EISSN: 1876-7486</identifier><identifier>DOI: 10.1016/j.phytol.2023.06.001</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>acid hydrolysis ; Biological activities ; Chromones ; glycosides ; Hypericum ; Hypericum elodeoides ; multiple drug resistance ; plant biochemistry ; Wessely Moser rearrangement</subject><ispartof>Phytochemistry letters, 2023-08, Vol.56, p.1-4</ispartof><rights>2023</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-f56f2a432d6291494b692d14956c702a3779f0d1e03c54db23de0ad075104df33</citedby><cites>FETCH-LOGICAL-c339t-f56f2a432d6291494b692d14956c702a3779f0d1e03c54db23de0ad075104df33</cites><orcidid>0000-0002-7892-011X ; 0009-0007-4409-2786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phytol.2023.06.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Mu, Yanbing</creatorcontrib><creatorcontrib>Cui, Letian</creatorcontrib><creatorcontrib>Ying, Ping</creatorcontrib><creatorcontrib>Wen, Huiping</creatorcontrib><creatorcontrib>Zhan, Dujuan</creatorcontrib><creatorcontrib>Kong, Lingyi</creatorcontrib><creatorcontrib>Luo, Jun</creatorcontrib><title>Chromones from the whole plant of Hypericum elodeoides and their bioactivities</title><title>Phytochemistry letters</title><description>Two chromones and four chromone C-glycosides (1-6), including the new 1, were isolated from the whole plant of Hypericum elodeoides. The structures were characterized by comprehensive analysis of their UV, NMR, ECD and HRESIMS data. The acid hydrolysis of Compounds 1, 2, 4 and 5 demonstrated that the chromone C-glycosides can undergo the Wessely Moser rearrangement. Compound 1 exhibited moderate α-glucosidase inhibitory activity (IC50: 456.26 ± 1.17 µM). Compound 4 could moderately reverse multidrug resistance with an IC50 value of 6.21 ± 0.40 μM (RF: 3.33) in MCF-7/Dox cells.
[Display omitted]
•Six chromones (1-6), including the new 1, were isolated from Hypericum elodeoides.•Chromone C-glycosides could undergo the Wessely-Moser rearrangement.•Chromones showed α-glucosidase inhibitory and anti-multidrug resistance activities.</description><subject>acid hydrolysis</subject><subject>Biological activities</subject><subject>Chromones</subject><subject>glycosides</subject><subject>Hypericum</subject><subject>Hypericum elodeoides</subject><subject>multiple drug resistance</subject><subject>plant biochemistry</subject><subject>Wessely Moser rearrangement</subject><issn>1874-3900</issn><issn>1876-7486</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhiMEEqXwDxgysiScP-I0CxKqgCJVsMBsufZFcZXUwXaL-u9xCTPTvcPznu6eLLslUBIg4n5bjt0xur6kQFkJogQgZ9mMLGpR1Hwhzn8zL1gDcJldhbAFEJxQMsvelp13g9thyNsU8thh_t25HvOxV7uYuzZfHUf0Vu-HHHtn0FmTYLUzJ9b6fGOd0tEebLQYrrOLVvUBb_7mPPt8fvpYror1-8vr8nFdaMaaWLSVaKnijBpBG8IbvhENNSlUQtdAFavrpgVDEJiuuNlQZhCUgboiwE3L2Dy7m_aO3n3tMUQ52KCxTzej2wfJSMUWvKFNnVA-odq7EDy2cvR2UP4oCciTPrmVkz550idByKQv1R6mGqY3Dha9DNriTqOxHnWUxtn_F_wAkDd61A</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Mu, Yanbing</creator><creator>Cui, Letian</creator><creator>Ying, Ping</creator><creator>Wen, Huiping</creator><creator>Zhan, Dujuan</creator><creator>Kong, Lingyi</creator><creator>Luo, Jun</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-7892-011X</orcidid><orcidid>https://orcid.org/0009-0007-4409-2786</orcidid></search><sort><creationdate>202308</creationdate><title>Chromones from the whole plant of Hypericum elodeoides and their bioactivities</title><author>Mu, Yanbing ; Cui, Letian ; Ying, Ping ; Wen, Huiping ; Zhan, Dujuan ; Kong, Lingyi ; Luo, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-f56f2a432d6291494b692d14956c702a3779f0d1e03c54db23de0ad075104df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>acid hydrolysis</topic><topic>Biological activities</topic><topic>Chromones</topic><topic>glycosides</topic><topic>Hypericum</topic><topic>Hypericum elodeoides</topic><topic>multiple drug resistance</topic><topic>plant biochemistry</topic><topic>Wessely Moser rearrangement</topic><toplevel>online_resources</toplevel><creatorcontrib>Mu, Yanbing</creatorcontrib><creatorcontrib>Cui, Letian</creatorcontrib><creatorcontrib>Ying, Ping</creatorcontrib><creatorcontrib>Wen, Huiping</creatorcontrib><creatorcontrib>Zhan, Dujuan</creatorcontrib><creatorcontrib>Kong, Lingyi</creatorcontrib><creatorcontrib>Luo, Jun</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Phytochemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mu, Yanbing</au><au>Cui, Letian</au><au>Ying, Ping</au><au>Wen, Huiping</au><au>Zhan, Dujuan</au><au>Kong, Lingyi</au><au>Luo, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromones from the whole plant of Hypericum elodeoides and their bioactivities</atitle><jtitle>Phytochemistry letters</jtitle><date>2023-08</date><risdate>2023</risdate><volume>56</volume><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>1874-3900</issn><eissn>1876-7486</eissn><abstract>Two chromones and four chromone C-glycosides (1-6), including the new 1, were isolated from the whole plant of Hypericum elodeoides. The structures were characterized by comprehensive analysis of their UV, NMR, ECD and HRESIMS data. The acid hydrolysis of Compounds 1, 2, 4 and 5 demonstrated that the chromone C-glycosides can undergo the Wessely Moser rearrangement. Compound 1 exhibited moderate α-glucosidase inhibitory activity (IC50: 456.26 ± 1.17 µM). Compound 4 could moderately reverse multidrug resistance with an IC50 value of 6.21 ± 0.40 μM (RF: 3.33) in MCF-7/Dox cells.
[Display omitted]
•Six chromones (1-6), including the new 1, were isolated from Hypericum elodeoides.•Chromone C-glycosides could undergo the Wessely-Moser rearrangement.•Chromones showed α-glucosidase inhibitory and anti-multidrug resistance activities.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.phytol.2023.06.001</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-7892-011X</orcidid><orcidid>https://orcid.org/0009-0007-4409-2786</orcidid></addata></record> |
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| ispartof | Phytochemistry letters, 2023-08, Vol.56, p.1-4 |
| issn | 1874-3900 1876-7486 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | acid hydrolysis Biological activities Chromones glycosides Hypericum Hypericum elodeoides multiple drug resistance plant biochemistry Wessely Moser rearrangement |
| title | Chromones from the whole plant of Hypericum elodeoides and their bioactivities |
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