Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

Inhibition of the electron transport chain (ETC) prevents the regeneration of mitochondrial NAD+, resulting in cessation of the oxidative tricarboxylic acid (TCA) cycle and a consequent dependence upon reductive carboxylation for aspartate synthesis. NAD+ regeneration alone in the cytosol can rescue...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2022-12, Vol.82 (23), p.4537-4547.e7
Hauptverfasser:	Altea-Manzano, Patricia, Vandekeere, Anke, Edwards-Hicks, Joy, Roldan, Mar, Abraham, Emily, Lleshi, Xhordi, Guerrieri, Ania Naila, Berardi, Domenica, Wills, Jimi, Junior, Jair Marques, Pantazi, Asimina, Acosta, Juan Carlos, Sanchez-Martin, Rosario M., Fendt, Sarah-Maria, Martin-Hernandez, Miguel, Finch, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	anaplerosis aspartate transaminase aspartic acid biosynthesis cancer cancer metabolism carbon carboxylation cell viability Citric Acid Cycle - physiology cytosol electron transport chain glutamate dehydrogenase malate dehydrogenase Malate Dehydrogenase - genetics Malate Dehydrogenase - metabolism malates metabolism mitochondria mitochondrion NAD - metabolism Oxidation-Reduction redox redox transfer Respiration succinic acid tricarboxylic acid cycle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!