Metagenomic insights into role of red mud in regulating fate of compost antibiotic resistance genes mediated by both direct and indirect ways
In this study, the amendment of red mud (RM) in dairy manure composting on the fate of antibiotic resistance genes (ARGs) by both direct (bacteria community, mobile genetic elements and quorum sensing) and indirect ways (environmental factors and antibiotics) was analyzed. The results showed that RM...
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| Veröffentlicht in: | Environmental pollution (1987) 2023-01, Vol.317, p.120795-120795, Article 120795 |
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| container_title | Environmental pollution (1987) |
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| creator | Huang, Yite Wen, Xiaoli Li, Jixuan Niu, Qiuqi Tang, Aixing Li, Qunliang |
| description | In this study, the amendment of red mud (RM) in dairy manure composting on the fate of antibiotic resistance genes (ARGs) by both direct (bacteria community, mobile genetic elements and quorum sensing) and indirect ways (environmental factors and antibiotics) was analyzed. The results showed that RM reduced the total relative abundances of 10 ARGs and 4 mobile genetic elements (MGEs). And the relative abundances of total ARGs and MGEs decreased by 53.48% and 22.30% in T (with RM added) on day 47 compared with day 0. Meanwhile, the modification of RM significantly increased the abundance of lsrK, pvdQ and ahlD in quorum quenching (QQ) and decreased the abundance of luxS in quorum sensing (QS) (P |
| doi_str_mv | 10.1016/j.envpol.2022.120795 |
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[Display omitted]
•Red mud reduced the concentration of residual antibiotics in composting.•The abundances of ARGs and MGEs were decreased by 53.48% and 22.30% with red mud.•Proteobacteria was the main contributor to ARGs and MGEs through network analysis.•The dissemination of ARGs was affected by red mud in both direct and indirect ways.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2022.120795</identifier><identifier>PMID: 36462475</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Actinobacteria ; Anti-Bacterial Agents - pharmacology ; antibiotic resistance ; Antibiotics ; Bacteria - genetics ; community structure ; Composting ; composts ; dairy manure ; Drug Resistance, Microbial - genetics ; Firmicutes ; Genes, Bacterial ; horizontal gene transfer ; Manure - microbiology ; metagenomics ; microbial communities ; Mobile genetic elements ; Network analysis ; organic matter ; pollution ; Proteobacteria ; Quorum sensing ; structural equation modeling ; temperature ; water content</subject><ispartof>Environmental pollution (1987), 2023-01, Vol.317, p.120795-120795, Article 120795</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-6f8ab399ac55bf5b45bf3c5eef4207b26103d52bf37eb196638bc3ea5024b1933</citedby><cites>FETCH-LOGICAL-a418t-6f8ab399ac55bf5b45bf3c5eef4207b26103d52bf37eb196638bc3ea5024b1933</cites><orcidid>0000-0002-0543-6351</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0269749122020103$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36462475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Yite</creatorcontrib><creatorcontrib>Wen, Xiaoli</creatorcontrib><creatorcontrib>Li, Jixuan</creatorcontrib><creatorcontrib>Niu, Qiuqi</creatorcontrib><creatorcontrib>Tang, Aixing</creatorcontrib><creatorcontrib>Li, Qunliang</creatorcontrib><title>Metagenomic insights into role of red mud in regulating fate of compost antibiotic resistance genes mediated by both direct and indirect ways</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>In this study, the amendment of red mud (RM) in dairy manure composting on the fate of antibiotic resistance genes (ARGs) by both direct (bacteria community, mobile genetic elements and quorum sensing) and indirect ways (environmental factors and antibiotics) was analyzed. The results showed that RM reduced the total relative abundances of 10 ARGs and 4 mobile genetic elements (MGEs). And the relative abundances of total ARGs and MGEs decreased by 53.48% and 22.30% in T (with RM added) on day 47 compared with day 0. Meanwhile, the modification of RM significantly increased the abundance of lsrK, pvdQ and ahlD in quorum quenching (QQ) and decreased the abundance of luxS in quorum sensing (QS) (P < 0.05), thereby attenuating the intercellular genes frequency of communication. The microbial community and network analysis showed that 25 potential hosts of ARGs were mainly related to Firmicutes, Proteobacteria and Actinobacteria. Redundancy analysis (RDA) and structural equation model (SEM) further indicated that RM altered microbial community structure by regulating antibiotic content and environmental factors (temperature, pH, moisture content and organic matter content), which then affected horizontal gene transfer (HGT) in ARGs mediated by QS and MGEs. These results provide new insights into the dissemination mechanism and removal of ARGs in composting process.
[Display omitted]
•Red mud reduced the concentration of residual antibiotics in composting.•The abundances of ARGs and MGEs were decreased by 53.48% and 22.30% with red mud.•Proteobacteria was the main contributor to ARGs and MGEs through network analysis.•The dissemination of ARGs was affected by red mud in both direct and indirect ways.</description><subject>Actinobacteria</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibiotic resistance</subject><subject>Antibiotics</subject><subject>Bacteria - genetics</subject><subject>community structure</subject><subject>Composting</subject><subject>composts</subject><subject>dairy manure</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Firmicutes</subject><subject>Genes, Bacterial</subject><subject>horizontal gene transfer</subject><subject>Manure - microbiology</subject><subject>metagenomics</subject><subject>microbial communities</subject><subject>Mobile genetic elements</subject><subject>Network analysis</subject><subject>organic matter</subject><subject>pollution</subject><subject>Proteobacteria</subject><subject>Quorum sensing</subject><subject>structural equation modeling</subject><subject>temperature</subject><subject>water content</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRAVHQp_gJCXbDL4FSfZIKGqFKQiNmVt2c7N1KMkHmynaD6Cf-ZOM7CEje_D55wrnUPIG862nHH9fr-F-fEQx61gQmy5YE1XPyMb3jay0kqo52TDhO6qRnX8krzMec8YU1LKF-RSaqWFauoN-fUVit3BHKfgaZhz2D2UjE2JNMURaBxogp5OS49LbHfLaEuYd3Sw5enXx-kQc6F2LsGFWFAmQQ652NkDRWXIdII-ILyn7khdLA-0Dwn8iXNSPQ8_7TG_IheDHTO8Ptcr8v3Tzf315-ru2-2X6493lVW8LZUeWutk11lf126oncJX-hpgUGiDE5oz2dcClw043mktW-cl2JoJhbOUV-TdqntI8ccCuZgpZA_jaGeISzaS17JFD1X3X6holJadxCsIVSvUp5hzgsEcUphsOhrOzCkzszdrZuaUmVkzQ9rb84XFoVN_SX9CQsCHFQBoyWOAZLIPgPauzpk-hn9f-A08LqwX</recordid><startdate>20230115</startdate><enddate>20230115</enddate><creator>Huang, Yite</creator><creator>Wen, Xiaoli</creator><creator>Li, Jixuan</creator><creator>Niu, Qiuqi</creator><creator>Tang, Aixing</creator><creator>Li, Qunliang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-0543-6351</orcidid></search><sort><creationdate>20230115</creationdate><title>Metagenomic insights into role of red mud in regulating fate of compost antibiotic resistance genes mediated by both direct and indirect ways</title><author>Huang, Yite ; Wen, Xiaoli ; Li, Jixuan ; Niu, Qiuqi ; Tang, Aixing ; Li, Qunliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-6f8ab399ac55bf5b45bf3c5eef4207b26103d52bf37eb196638bc3ea5024b1933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Actinobacteria</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibiotic resistance</topic><topic>Antibiotics</topic><topic>Bacteria - genetics</topic><topic>community structure</topic><topic>Composting</topic><topic>composts</topic><topic>dairy manure</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Firmicutes</topic><topic>Genes, Bacterial</topic><topic>horizontal gene transfer</topic><topic>Manure - microbiology</topic><topic>metagenomics</topic><topic>microbial communities</topic><topic>Mobile genetic elements</topic><topic>Network analysis</topic><topic>organic matter</topic><topic>pollution</topic><topic>Proteobacteria</topic><topic>Quorum sensing</topic><topic>structural equation modeling</topic><topic>temperature</topic><topic>water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yite</creatorcontrib><creatorcontrib>Wen, Xiaoli</creatorcontrib><creatorcontrib>Li, Jixuan</creatorcontrib><creatorcontrib>Niu, Qiuqi</creatorcontrib><creatorcontrib>Tang, Aixing</creatorcontrib><creatorcontrib>Li, Qunliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Yite</au><au>Wen, Xiaoli</au><au>Li, Jixuan</au><au>Niu, Qiuqi</au><au>Tang, Aixing</au><au>Li, Qunliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metagenomic insights into role of red mud in regulating fate of compost antibiotic resistance genes mediated by both direct and indirect ways</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2023-01-15</date><risdate>2023</risdate><volume>317</volume><spage>120795</spage><epage>120795</epage><pages>120795-120795</pages><artnum>120795</artnum><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>In this study, the amendment of red mud (RM) in dairy manure composting on the fate of antibiotic resistance genes (ARGs) by both direct (bacteria community, mobile genetic elements and quorum sensing) and indirect ways (environmental factors and antibiotics) was analyzed. The results showed that RM reduced the total relative abundances of 10 ARGs and 4 mobile genetic elements (MGEs). And the relative abundances of total ARGs and MGEs decreased by 53.48% and 22.30% in T (with RM added) on day 47 compared with day 0. Meanwhile, the modification of RM significantly increased the abundance of lsrK, pvdQ and ahlD in quorum quenching (QQ) and decreased the abundance of luxS in quorum sensing (QS) (P < 0.05), thereby attenuating the intercellular genes frequency of communication. The microbial community and network analysis showed that 25 potential hosts of ARGs were mainly related to Firmicutes, Proteobacteria and Actinobacteria. Redundancy analysis (RDA) and structural equation model (SEM) further indicated that RM altered microbial community structure by regulating antibiotic content and environmental factors (temperature, pH, moisture content and organic matter content), which then affected horizontal gene transfer (HGT) in ARGs mediated by QS and MGEs. These results provide new insights into the dissemination mechanism and removal of ARGs in composting process.
[Display omitted]
•Red mud reduced the concentration of residual antibiotics in composting.•The abundances of ARGs and MGEs were decreased by 53.48% and 22.30% with red mud.•Proteobacteria was the main contributor to ARGs and MGEs through network analysis.•The dissemination of ARGs was affected by red mud in both direct and indirect ways.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36462475</pmid><doi>10.1016/j.envpol.2022.120795</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0543-6351</orcidid></addata></record> |
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| ispartof | Environmental pollution (1987), 2023-01, Vol.317, p.120795-120795, Article 120795 |
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| subjects | Actinobacteria Anti-Bacterial Agents - pharmacology antibiotic resistance Antibiotics Bacteria - genetics community structure Composting composts dairy manure Drug Resistance, Microbial - genetics Firmicutes Genes, Bacterial horizontal gene transfer Manure - microbiology metagenomics microbial communities Mobile genetic elements Network analysis organic matter pollution Proteobacteria Quorum sensing structural equation modeling temperature water content |
| title | Metagenomic insights into role of red mud in regulating fate of compost antibiotic resistance genes mediated by both direct and indirect ways |
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