Zhen-wu-tang protects against myocardial fibrosis by inhibiting M1 macrophage polarization via the TLR4/NF-κB pathway

•ZWT showed significantly therapeutic effects on ISO-induced myocardial fibrosis in mice.•ZWT inhibited myocardial fibrosis by inhibiting M1 type macrophage polarization.•ZWT inhibited M1 type macrophage polarization through preventing the activation of TLR4/NF-κB signalling pawthway. Myocardial fib...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-07, Vol.130, p.155719, Article 155719
Hauptverfasser:	Fang, Rong, Zhou, Rui, Ju, Di, Li, Mi, Wang, Haifang, Pan, Liangliang, Wang, Xueqing, Han, Man, Yu, Yuanwang
Format:	Artikel
Sprache:	eng
Schlagworte:	cardiac output cardiovascular diseases collagen death drugs echocardiography electrocardiography fibrosis fluorescent antibody technique heart human health Inflammation isoproterenols lipopolysaccharides M1 type macrophages macrophages mice Myocardial fibrosis protective effect quantitative polymerase chain reaction risk factors therapeutics TLR4/NF-κB signalling pathway transfection Zhen-wu-tang
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